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小剂量芬太尼伍用曲马多静注治疗开胸后镇痛效果观察 被引量:4

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摘要 目的行不同剂量曲马多复合小剂量芬太尼行开胸术后静脉镇痛效果及不良反应的观察。方法 60例ASAⅠ~Ⅱ级开胸手术患者,随机分为三组,每组20例。A组镇痛药物配制:芬太尼0.1mg+曲马多10mg/kg+氟哌利多3mg,用0.9%生理盐水稀释至100ml;B组:芬太尼0.1mg+曲马多12mg/kg+氟哌利多3mg,用0.9%生理盐水稀释至100ml;C组:芬太尼0.1mg+曲马多14mg/kg+氟哌利多3mg,用0.9%生理盐水稀释至100ml,三组患者均在手术结束后行静脉术后镇痛。观察并记录患者术后6小时(T1)、12小时(T2)、24小时(T3)、48小时(T4)的静息疼痛评分及患者48小时内出现恶心、呕吐和皮肤瘙痒等不良反应例数。结果 B、C组T1、T2、T3时间点VAS评分低于A组(p<0.05);A、B组术后恶心呕吐等副作用发生率比C组相对较低(p<0.05)。结论 B组镇痛药物配伍既可提供有效的胸科术后镇痛且相对副作用较少,可适用于胸科手术术后镇痛。
机构地区 广州市胸科医院
出处 《临床肺科杂志》 2010年第7期1016-1017,共2页 Journal of Clinical Pulmonary Medicine
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