摘要
目的探讨中期因子(MK)在宫颈癌组织中表达的临床意义。方法采用免疫组化链霉菌抗生物素蛋白一过氧化酶联结法(SP)检测134例宫颈癌、42例宫颈上皮内瘤样病变和46例慢性宫颈炎组织MK的阳性表达情况,比较不同宫颈疾病组织中MK表达有无差异及比较宫颈癌组织中MK表达在不同临床分期、组织分化程度、有无淋巴转移病理类型有无差异。结果慢性宫颈炎、宫颈上皮内瘤样病变和宫颈癌组织中MK的阳性表达率分别为8.7%、26.8%和76.1%,宫颈癌组织中MK的阳性表达率高于慢性宫颈炎、宫颈上皮内瘤样病变,差异有统计学意义(P<0.05),慢性宫颈炎组织与宫颈上皮瘤样病变组织中MK阳性表达率比较,差异有统计学意义(P<0.05)。宫颈癌组织中MK的阳性表达率与宫颈癌组织分化程度、临床分期和淋巴结转移有关,差异均有统计学意义(P<0.05)。结论 MK可能与宫颈癌的发生、发展有关,对宫颈癌的早期诊断及治疗有一定的临床指导意义。
Objective To evaluate the expression of midkine in cervical cancer and its clinical significance.Methods Immunohistochemical streptomyces avidin-peroxidase link method was used to detect MK positive expression in 134 patients with cervical cancer,42 with cervical intraepithelial neoplasia and 46 with chronic cervicitis.MK expression in different cervical disease tissues and in different clinical stages,histodifferentiation,pathological type of lymphatic metastasis of cervical cancer tissues were compared.Results MK positive expressions in tissues of chronic cervicitis,cervical intraepithelial neoplasia and cervical cancer were,respectively,MK positive rate was higher in cervical cancer tissues than in chronic cervicitis and cervical intraepithelial neoplasia,the difference was significant （P0.05）,there was significant difference in MK positive rate between chronic cervicitis and cervical intraepithelial neoplasia （P0.05）.MK positive expression in cervical cancer tissues was related to differentiation,clinical staging,lymph node metastasis,the difference was significant （P0.05）.Conclusion MK,probably related to the genesis and development of cervical cancer,is of some clinical significance in early diagnosis and treatment of cervical cancer.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第15期1613-1614,共2页
Chinese General Practice
