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中期因子与卵泡发育的研究进展

Research progress on midkine and follicular development
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摘要 中期因子(midkine)属于肝素结合生长因子家族中的新成员,是一种强有力的刺激细胞增殖的调节因子,表达于卵泡颗粒细胞等组织,具有抑制卵丘颗粒细胞凋亡等广泛的生物学作用。在卵泡发育过程中midkine能促进卵母细胞的发育成熟,特别是对细胞质的成熟有着重要的作用,能够提高其受精率、胚胎卵裂率和囊胚率。 Midkine is a new family member of heparin-binding growth/differentiation factors that can stimulate cell proliferation strongly. It is located in granulosa cells of follicles and other tissues, and plays exclusively biological roles of inhibiting granulosa cells apoptosis. During the process of follicular development, midkine increases oocytes maturation, especially the cytoplasmic maturation, and improved the fertilization rate, cleavage rate and the blastocyst yield.
作者 唐飞 周颖
机构地区 温州医学院 温州医学院附属第一医院生殖医学中心
出处 《生殖医学杂志》 CAS 2009年第3期317-320,共4页 Journal of Reproductive Medicine
关键词 中期因子 卵泡发育 凋亡 颗粒细胞 Midkine Follicular development Apoptosis Granulosa cell
分类号 R711.6 [医药卫生—妇产科学] R735.7 [医药卫生—肿瘤]
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参考文献25

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二级参考文献19

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生殖医学杂志
2009年 第3期

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