摘要
目的研究人乳头瘤病毒(HPV)亚型感染的情况,探讨HPV DNA检测在宫颈癌防治方面的意义。方法应用DNA杂交技术对3700例妇科门诊患者进行HPV基因分型检测。结果 3700例患者中,HPV感染者1071例,HPV感染率为28.95%,HPV感染1400人次。患者中高危型HPV(16、18、31、33、35、39、45、51、52、56、58、59、68)1124人次,占感染总人次的80.29%;低危型HPV(6、11、42、43、44)151人次,占感染总人次的10.79%;中国人群常见型HPV(53、66、P8304)125人次,占感染总人次的8.93%。21种HPV基因亚型多重感染患者250例,占HPV感染者的23.34%。其中双重感染者占多重感染者的77.60%。结论 DNA杂交技术检测HPV基因分型,可一次检测多种亚型,有利于对HPV多重感染的诊断和宫颈癌的防治,可作为宫颈癌筛查的手段。
Objective To investigate the distribution of human papillomavirus （HPV） genotype infections and to explore the application of HPV DNA test in the prevention and treatment of cervix cancer.Methods Totally 3700 women were detected for HPV genotyping by using DNA hybridization technique.Results Of these 3700 women,1071 women （28.95%） were found to be HPV-positive.Among 1400 cases of HPV infection 1124 （80.29%） were infected with high-risk HPV types （HPV-16,18,31,33,35,39,45,51,52,56,58,59,and 68）,151 （10.79%） were with low-risk types （HPV-6,11,42,43,and 44）,and 125 （8.93%） were with some common types （HPV-53,66,and P8304） among Chinese women.Multi-HPV infection was observed in 250 women （23.34%）,among which 194 women （77.60%） had double infections.Conclusion DNA hybridization technique is useful for the diagnosis of multi-HPV infection and therefore for the prevention and treatment of cervical cancer.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第15期1611-1612,共2页
Chinese General Practice
关键词
宫颈肿瘤
人乳头瘤病毒
DNA杂交技术
感染
Cervix neoplasms
Human papillomavirus
DNA hybridization technique
Infection
