摘要
目的观察替罗非班对ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入术(PCI)后心肌灌注和临床预后的影响。方法选择75例符合直接PCI的急性STEMI患者,随机分为替罗非班实验组(38例)和对照组(37例),实验组在PCI基础上加替罗非班,对照组直接行PCI,观察两组术后心肌缺血再灌注损伤,住院期间主要心血管事件(MACE)及临床预后。结果治疗组在PCI术前后冠脉TIMI以及TMP分级、心电图ST段回落、7d后左心室射血分数(LVEF)、主要心血管事件(MACE)发生率等方面显著优于对照组,术后肌钙蛋白I(cTnI)峰值、住院天数、出血并发症、住院期间主要心血管事件(MACE)两组之间无差异。结论对于急性STEMI行PCI前应用替罗非班可更有效地改善冠脉血流及临床预后,方法安全。
Objective To observe the impact of the tirofiban on myocardial perfusion and clinical prognosis of patients with acute ST segment elevation myocardial infarction（STEMI）after direct percutaneous coronary intervention（PCI）.Methods 75 acute STEMI patients suitable for direct PCI were randomly divided into experimental group with tirofiban（38 cases）and control group（37 cases）.During the PCI,tirofiban were used in experimental group while not in control group,and then to observe the two groups the myocardial ischemia-reperfusion injury,major cardiovascular events（MACE）during hospitalization and clinical prognosis.Results The experimental group were significantly superior to the control group on coronary TIMI and TMP grade,ST segment resolution,the left ventricular ejection fraction（LUEF）7 days later and the incidence of major cardiovascular events（MACE）before and after the PCI.Moreover,there were no differences between the two groups on troponin I（cTnI）peak,hospitalization days,bleeding complications and major cardiovascular events（MACE）during hospitalization.Conclusion For acute STEMI,using tirofiban before PCI can effectively improve myocardial perfusion and clinical prognosis,which is a safe method.
出处
《海南医学》
CAS
2010年第11期7-9,共3页
Hainan Medical Journal
关键词
心肌梗死
心肌灌注
冠状动脉介入术
替罗非班
Myocardial infarction
Myocardial perfusion
Coronary intervention
Tirofiban
