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miR-34家族——肿瘤抑制蛋白p53高度相关的microRNA 被引量：16

miR-34s—a tumor suppression protein p53 highly related microRNA
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摘要 若干微小RNA(microRNA,miRNA)与肿瘤抑制蛋白p53高度相关,其中miR-34家族最具代表性。一方面p53可通过对miR-34家族的调控实现对多个原癌基因如Bcl-2、c-myc以及细胞因子如cyclinE2、cyclinD1和c-Met的抑制,进而发挥抑癌作用;另一方面miR-34家族也可以通过抑制沉默信息调节子SIRTI来进一步增强p53的活性。p53与miR-34家族之间形成的正反馈调节网络对抑制肿瘤的发生发展及恶化均起着重要的作用。文章对p53高度相关的miR-34家族在肿瘤发生发展及治疗的最新进展作一论述。 Several microRNAs,most representatively the miR-34,are highly related to tumor suppression protein p53.p53 exerts its tumor suppression function known as inhibiting multiple-oncogenes,such as Bcl-2,c-myc and cell cytokines such as cyclinE2,cyclinD1 and c-Met through the regulation of miR-34.On the other hand,miR-34 enhances the activities of p53 by inhibiting silence information regulator I（SIRTI）.The positive feedback regulatory network based on p53 and miR-34 families play an important role in suppression of oncogenesis and deterioration.This paper summarizes the latest advances of p53 highly related miR-34 families in oncogenesis and treatment.
作者 娄文加 陈青 刘立 钱程
机构地区 浙江理工大学生命科学学院
出处 《遗传》 CAS CSCD 北大核心 2010年第5期423-430,共8页 Hereditas（Beijing)
基金 国家自然科学基金项目(编号:30872984) 浙江省重中之重学科开放基金项目(编号:SWYX0816)资助
关键词 miR-34家族 P53 反馈调节 miR-34s p53 feedback regulation
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献39

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二级参考文献23

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共引文献14

同被引文献106

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引证文献16

二级引证文献46

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