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孤独症患儿胼胝体磁共振形态及扩散张量成像 被引量：7

Structural MRI and diffusion tensor imaging of corpus callosum in autism
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摘要 目的通过胼胝体磁共振形态及扩散张量成像(DTI)观察孤独症患儿胼胝体形态及细微结构异常,探讨其可能的发生机制。方法对13例男性孤独症患儿(孤独症组)及15名正常男童(正常对照组)进行胼胝体结构磁共振形态及DTI观察,测量胼胝体正中矢状面前部、体部、后部及总面积,大脑总体积及各相异性分数(FA),并对两组进行对比分析。结果孤独症组胼胝体前部面积及总面积较正常对照组减小(P<0.05),体部和后部面积与对照组差异无统计学意义(P>0.05);大脑总体积较对照组增大(P<0.05)。孤独症组患者胼胝体前部和体部的FA值明显低于正常对照组(P<0.05),后部的FA值两组间差异无统计学意义(P>0.05)。结论孤独症患儿胼胝体前部面积较正常发育儿童明显减小,胼胝体前部及体部FA值明显降低,提示胼胝体局部白质纤维束可能存在微结构的改变。 Objective To investigate the microstructural abnormalities of the corpus callosum （CC） in autism with structural imaging and diffusion tensor imaging （DTI）, and to detect it＇s mechanisms. Methods Thirteen autistic boys （autism group） and 15 healthy boys （control group） underwent MR structural DTI and scanning. The areas of 3 subregions （anterior, body and posterior） and their total area, total brain volume （TBV） and fractional anisotropy （FA） value of the CC were measured and compared between the two groups. Results The anterior and total area of the CC in autism group were lower than those in control group （P〈0.05）, but no statistical difference was found in body and posterior CC （P〉0.05）. TBV in autism group was significantly larger than that in control group （P〈0. 05）. FA value in the anterior and body of CC was lower than that in control group （P〈0.05）, but no difference was found in posterior CC between two groups （P〉0.05）. Conclusion There may be disruption of regional white matter tracts in the anterior and body of the corpus caliosum in patients with autism.
作者 白芝兰 戚威 张晓娜 李敏
机构地区 西安交通大学医学院第二附属医院影像科 西安交通大学医学院第一附属医院影像科
出处 《中国医学影像技术》 CSCD 北大核心 2010年第5期825-827,共3页 Chinese Journal of Medical Imaging Technology
关键词 孤独症 胼胝体 磁共振成像 扩散磁共振成像 Autism Corpus ealiosum Magnetic resonance imaging Diffusion magnetic resonance imaging
分类号 R445.2 [医药卫生—影像医学与核医学] R749.94 [医药卫生—神经病学与精神病学]
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参考文献12

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共引文献36

同被引文献42

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引证文献7

二级引证文献41

中国医学影像技术
2010年 第5期

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