摘要
肺炎链球菌是引起菌血症、败血症、脑膜炎、脓胸等侵袭性疾病的主要致病菌之一,但不同地域、不同人群中侵袭性肺炎链球菌疾病(IPD)的发病率有显著差异,另外,肺炎链球菌血清型的变化、毒力强弱、机体的免疫应答情况等均与疾病的严重程度及病死率密切相关。常规接种肺炎链球菌疫苗是预防肺炎链球菌感染的重要措施,不仅可为接种者提供良好的保护作用,而且还能产生群体免疫效果。现简要介绍IPD的发病机制、危险因素及防治策略。
Streptococcus pneumoniae is one of the most common cause of invasive disease,such as bacteremia,meningitis,and empyema,et al.But there has significant difference on the incidence of invasive pneumococcal disease among different regions and differernt groups of people.In addition the severity and mortality of invasive pneumococcal disease are closely related to the changes of serotypes,virulence of streptococcus pneumoniae and also the human immune response.The pneumococcal vaccination is an important measure to prevent streptococcus pneumoniae infection,providing good protection to vaccinees and createing herd immunity effect.This article briefly describes the pathogenesis,risk factors and preventive strategies of invasive pneumococcal disease.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第10期776-778,共3页
Journal of Applied Clinical Pediatrics
