摘要
以丁二酸酐为原料,分别与2-氨基吡啶、N-甲基哌嗪、对氯苯胺、苯胺、叔丁胺进行酰化反应合成了相应的N-取代丁二酸一酰胺目标化合物Ⅰ、Ⅱ、Ⅲ、Ⅳ、和Ⅴ,该类反应的最佳反应条件为:丁二酸酐与胺类化合物的反应摩尔配比为1∶1,反应温度15℃,反应时间为5 h,反应介质二氯甲烷的用量为160 mL。在优化条件下,目标化合物Ⅰ、Ⅱ、Ⅲ、Ⅳ、和Ⅴ的最高产率分别为85.6%、82.4%、78.4%、74.3%和71.9%。合成产品均通过重结晶进行了纯化,并通过核磁共振氢谱进行了确证。
With succinic anhydride as the raw material, five N -substituted succinamic acid compounds were synthesized by its acylating reaction with 2-amino pyridine, N-methyl piperazine, p-chloroaniline, aniline, tertiary butyl amine, respectively. The optimum reaction conditions are as follows： the ratio of succinic anhydride to amine is 1：1 ; the reaction temperature is 15 ℃ and reaction time 5 hours; the dosage of diehloromethane as reaction medium is 160 mL. The highest yield of five object compounds is 85.6% ,82.4% ,78.4% ,74.3% and 71.9%, respectively. The synthetic products are purified through re-crystallization and their structures are characterized by the ^1HNMR.
出处
《辽东学院学报（自然科学版）》
CAS
2010年第1期1-4,共4页
Journal of Eastern Liaoning University:Natural Science Edition
关键词
N-取代琥珀酰胺酸
N-酰化反应
丁二酸酐
合成
N-substituted suceinamic acid
N-acylating reaction
succinie anhydride
synthesis
