摘要
目的探讨转化生长因子TGFβ1 869基因多态性与阿尔茨海默病的关系。方法运用多聚酶链反应技术检测66例阿尔茨海默病及143例正常人转化生长因子TGFβ1 T869C基因多态性。结果 AD组转化生长因子TGFβ1 869基因多态性基因型频率(%)分别为0.1969、0.4848、0.3183,对照组分别为0.2168、0.4755、0.3078,转化生长因子TGFβ1 869基因多态性各种基因型频率在患者组与正常对照组之间的差异无统计学意义(P>0.05)。结论转化生长因子TGFβ1 869基因多态性与AD无明显相关。
Objective To explore relationship of polymorphism of transforming growth factor （TGF） β1 869 gene with Alzheimer diseases. Methods The genotyes of TGFβ1 869 gene were determined by PCR-based assay in 66 patients with Alzheimer disease and 143 healthy controls. Results The gene frequencies of polymorphism of TGFβ1 869 in AD group were 0.1969, 0.4848 and 0.3183, and they were 0.2168, 0.4755 and 0.3078 in control group. There were no significant differences in the frequenceies of TGFβ1 869 gene mutations between the patients and central groups （P〉0.05）. Conclusion The polymor- phism of TGFβ1 869 gene may not be independent risk factors for Alzheimer disease.
出处
《解剖学研究》
CAS
2010年第2期93-95,120,共4页
Anatomy Research
基金
广州市卫生局科研立项项目(2009-YB-240)
