摘要
目的：研究组织因子途径抑制物（Ｔｉｓｓｕｅ Ｆａｃｔｏｒ Ｐａｔｈｗａｙ Ｉｎｈｉｂｉｔｏｒ，ＴＦＰＩ）这一新型抗凝蛋白在脑出血与脑梗塞中的表达，探索其临床意义。方法：ＴＦＰＩ抗原（ＴＦＰＩ：Ａｇ）采用双夹心ＥＬＩＳＡ抗原测定法，ＴＦＰＩ活性（ＴＦＰＩ：Ａ）采用发色底物法。结果：脑出血（ ｎ＝１６）与脑梗塞（ ｎ＝４６）的 ＴＦＰＩ抗原与活性均高于对照组。有并发感染或并发糖尿病，高脂血症组高于无并发症组。结论：脑出血或脑梗塞患者出血管病变与血小板活化 ＴＦＰＩ增高，提示感染对血管内皮的持续损伤与某些炎症因子能刺激其释放。
Objective: Evaluation of clinical significance in determination of tissue factor pathway inhibitor (TFPI)ma new type anticoagulation protein levels in plasma with the patients of cerebral hemorrhage and cerebral infarction. Methods: TFPI antigen (TFPI:Ag) was determined with an enzyme linked immunity (ELISA). TFPI active (TFPI: A) was determined with chromogenic peptide substrate method. Results: TFPI: Ag/TFPI: A of cerebral hemorrhage and cerebral infarction were higher than controls. Complication with infetious or diabetes mellitus, hyperlipemia were higher than no complication groups. Conclusions: Due to lesion of vaso-endothelial and actirity of platelet with the patients of cerebral hemorrhage and cerebral infarction,so the TFPI was increased,all the same,TFPI was increased persistent on the complication groups. It attributed to vasoendothelial cell persistent injury by infectious,also inflammation factor could irritate TFPI release.
出处
《临床血液学杂志》
CAS
1999年第2期58-60,共3页
Journal of Clinical Hematology
关键词
脑出血
脑梗塞
组织因子抑制物
TFPI
病理
Cerebral hemorrhage
Cerebral infarction
Tissue factor pathway inhibitor
