摘要
RNA干扰(RNAi)是利用同源性双链RNA诱发序列特异的转录后基因沉默现象,是研究基因功能的重要工具。表皮生长因子受体在皮肤鳞状细胞癌中过度表达,且EGFR信号通路的启动后可促进细胞增殖、转移、血管生成及阻断细胞凋亡,因此被作为开发肿瘤治疗方法的新靶点。现将对RNA干扰表皮生长因子受体在皮肤鳞状细胞癌中的治疗作用予以综述。
RNA interference（RNAi）is a phenomenon of post-transcriptional genes silencing induced by sequence-specific double-stranded RNA（dsRNA）.RNAi has become an important tool in the filed of gene therapy.EGFR is over-expressed in cutaneous squamous cell carcinoma,triggering a cascade of downstream signals if activated and resulting in an increase of cellular proliferation,metastasis angiogenesis and blockade of cells apoptosis,which has been developed as a new target for tumor therapy.In this review,we focus on the potential therapeutic use of EGFR targeted RNAi on cutaneous squamous cell carcinoma.
出处
《医学综述》
2010年第10期1482-1484,共3页
Medical Recapitulate
基金
江苏省教育厅2008年度省属高校自然科学基础研究面上项目(08KJD320009)
关键词
表皮生长因子受体
小干扰RNA
皮肤鳞癌
Epidermal growth factor receptor
RNA interference
Cutaneous squamous cell carcinoma
