摘要
目的验证模拟失重４ｗｋ大鼠心脏左室的结构与功能是否出现类似航天员飞行后的变化。方法应用超声心动图技术检测模拟失重大鼠心脏左室的结构与功能。结果模拟失重４ｗｋ大鼠左室舒张末与收缩末短径均显著减小；左室壁厚度亦减小，但差别未达显著程度。左室舒张末与收缩末容积、每搏量及其相应的体重归一化指数皆显著减少，左室估计质量及其指数亦显著减少。但左室射血分数与短轴收缩率，主动脉瓣、肺动脉瓣及二尖瓣处多普勒峰值血流速度则皆无显著改变。结论４ｗｋ模拟失重大鼠左室的超声心动图表现类似航天员飞行后的变化。其主要改变为：左室心腔短径变短，左室壁厚度呈减小趋势，左室估计容积与质量皆显著减少，但一些心肌收缩功能指标却未见有明显变化。
Objective To investigate
whether the changes in rat after simulated weightlessness are similar to those in astronaut
after flight. Methods The effects of 4 wk tail suspension on left ventricular structure and
function in rats were examined by echocardiography. Results After 4 wk of simulated
weightlessness,the thickness of both the anterior and posterior wall in left ventricle (LV) showed
a general trend of decrease, but these changes were not statistically significant; the end
systolic and end diastolic internal dimensions (ESD and EDD respectively) of LV decreased
significantly; and the end systolic volume, end diastolic volume and stroke volume (ESV, EDV
and SV respectively) were all reduced; so did the relevant indices of them. There were no
significant differences in ejection fraction (EF) and fractional shortening (FS) between the tail
suspended and control groups. The left ventricular mass (LVM) and its index (LVMI) were
decreased. The peak velocities of blood flow of aorta, pulmonary artery and mitral valve didn't
show any significant change after simulated weightlessness. Conclusion Medium term
simulated weightlessness may lead to a significant decrease in left ventricular internal
dimension, ventricular volume, and mass, and a trend of decrease in mean left ventricular wall
thickness. These changes in rats are similar to those observed in astronauts postflight.
出处
《航天医学与医学工程》
CAS
CSCD
1999年第2期88-91,共4页
Space Medicine & Medical Engineering
基金
国家自然科学基金
