摘要
目的探讨放化疗联合树突细胞-细胞因子诱导的杀伤细胞(DC-CIK)对结直肠癌的疗效。方法回顾性分析51例结直肠癌根治术后行放化疗联合HPS70(Heat Shock Protain70)负载的DC-CIK细胞疗法患者的临床资料,采用1∶1配对的方法 ,以性别、年龄、部位、病理分期、AJCC(1997)中临床分期、术后辅助化疗方案、是否接受术后辅助放疗为指标,在同期行结直肠癌根治术但未行DC-CIK细胞疗法的患者中选择51例作为对照,比较两组患者3年生存率(OS)和3年无病生存率(DFS)。结果 DC-CIK治疗组及对照组3年生存率分别为88.2%和68.6%,两者比较差异具有显著性(P<0.05)。DC-CIK治疗组及对照组3年无病生存率分别为43.1%和27.5%,两者比较差异具有显著性(P<0.05)。结论结直肠癌根治术后放化疗联合DC-CIK细胞疗法,能明显提高患者的远期生存率和无病生存率。
Objective To evaluate the effect of chemotherapy and radiotherapy combined with DC-CIK in the treatment of colorectal cancer after radical resection.Methods The clinical data were retrospectively reviewed of 51 patients treated by adjuvant chemotherapy and radiotherapy combined with DC-CIK loaded with heat shock protain 70（HSP70）after radical resection.A cohort of 51 patients with colorectal cancer treated by adjuvant chemotherapy and radiotherapy only were chosen in respect of gender,age,location of the tumor,histologic type,the AJCC（1997）＇s stage,adjuvant chemotherapy programs,whether or not receiving adjuvant radiotherapy.Results The 3-year survival rate in the DC-CIK treatment group was significantly higher than that in the control group（P0.05）.The 3-year disease-free survival rate in the DC-CIK treatment group is significantly higher than that in the control group（P0.05）.Conclusion chemotherapy and radiotherapy combined with DC-CIK could improve the disease-free survival and the overall survival of patients with colorectal cancer.
出处
《实用癌症杂志》
2010年第3期274-276,282,共4页
The Practical Journal of Cancer
基金
福建省科技计划重点资助项目(2007Y0014)
关键词
结直肠癌
热休克蛋白
DC-CIK细胞
无病生存率
Colorectal cancer
Heat shock protain
DC-CIK cells
The disease-free survival rates
