摘要
目的检测了ｎｍ２３－Ｈ１基因产物ｎｍ２３－Ｈ１蛋白在７０例大肠癌中的表达，就其临床意义进行探讨。方法免疫组化ＬＳＡＢ方法。结果ｎｍ２３－Ｈ１蛋白在大肠癌中有较高的表达，阳性率为４４．３％；分化程度高者阳性率高于分化程度低者，有淋巴结转移的表达阳性率（２３．１％）明显低于无转移者（７０．９％），表达阳性率随分期的进展逐渐下降，与预后呈正相关。ｎｍ２３－Ｈ１蛋白在大肠癌的分化发展中起一定的作用。
Objective To examin the expressione of gene nm23 in human colon cancer and its clinical significace.Methods Labeled streptavidin biotin(LSAB) was used.Results Of 70 patients tested ,31 (44.3%) showed positive staining. The positive staining rate was higher in well differentiated cancer than in poorly differentiated cancer .In patients with lymph node metastasis,the positive staining rate was lower than in those without lymph node metastasis. Inverse relationship wase found between gene nm23 H1 expression and clinical status.Conclusion The expression of nm23 H1 may play a role in the development of human colon cencer .It suggested that the expression of nm23 H1 may serve as a indicator to predict the prognosis of patients with colon cancer.
出处
《肿瘤研究与临床》
CAS
1999年第1期11-12,共2页
Cancer Research and Clinic
