摘要
目的:了解碳青霉烯类药物与青霉素交叉过敏反应的特点及规律。方法:报道厄他培南与青霉素交叉过敏的病历资料2例,并检索1986年1月～2010年1月多个数据库的相关文献,收集到碳青霉烯类与青霉素交叉过敏相关文献9篇共716例,进行统计、分析。结果:有青霉素过敏史患者发生碳青霉烯类药物过敏反应的几率高于无青霉素过敏者,过敏反应可发生于用药后15min～49d,及时撤药或经抗过敏治疗后患者转归均较好。结论:临床应重视碳青霉烯类与青霉素交叉过敏反应的监测,坚持合理选药。
OBJECTIVE：To analyze the characteristics and regularity of cross allergic reaction between carbopenems and penicillin.METHODS：2 cases about cross allergic reaction between ertapenem and penicillin were reported,716 cases of cross allergic reaction between carbopenems and penicillin in 9 literatures were collected from databases from Jan.1986 to Jan.2010 and analyzed statistically.RESULTS：The incidence of allergic reactions caused by carbopenems in patients with allergic history were higher than that in patients without allergic history.Allergic reaction mostly occurred within 15 min～49 d.Sound therapeutic efficacy can be achieved because of immediate withdrawal of drug and anti-allergy treatment,patients were with good prognosis.CONCLUSION：Great importance should be attached to monitoring of cross allergic reaction between carbopenems and penicillin and rational use of drugs.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第20期1892-1893,共2页
China Pharmacy
