摘要
为了对炎琥宁中3个主要有关物质的结构进行鉴定,采用制备高效液相法分离杂质,并应用LC-ESI/TOFMS、LC-ESI/MSn、NMR、UV、IR等对主要有关物质进行结构鉴定。结果发现其中一个杂质是炎琥宁的水解氧化产物,另外两个杂质是炎琥宁水解掉不同琥珀酸形成的单酯。由此表明炎琥宁容易被水解和氧化,应在阴凉干燥处保存。
To identify the structure of three related substances in potassium sodium dehydroandrographolide succinate （PSDS）,an HPLC preparation method was used to separate the impurities.These main impurities were identified using LC-ESI/TOFMS,LC-ESI/MSn,NMR,UV and IR.One of the main impurities was a hydrolyzed and oxidized product of PSDS,which has not been reported previouely.The other two impurities were hydrolyzed products of PSDS after losing different succinic acids.The results indicate that PSDS can be easily hydrolyzed and oxidized.It should be stored at cool and dry places.
出处
《药学学报》
CAS
CSCD
北大核心
2010年第5期641-646,共6页
Acta Pharmaceutica Sinica
关键词
炎琥宁
有关物质
结构鉴定
LC-MS
potassium sodium dehydroandrographolide succinate
related substance
structure identification
LC-MS
