摘要
目的探讨复方磷酸可待因糖浆联合氨溴索治疗稳定期慢性阻塞性肺疾病（COPD）中的疗效及安全性。方法稳定期COPD患者100例，分为复方磷酸可待因糖浆＋氨溴索组（A组）50例和复方磷酸可待因糖浆（B组）50例，均用药3～7d。比较两组治疗前后症状评分及疗效。结果治疗第8天，患者咳嗽、痰量、痰黏度、喘息、睡眠症状评分与治疗前有明显改善（X^2=3．891，X^2=3．992，x^2=4．198，x^2=3．981，X^2=3．879，均P〈0．05）；A组咳嗽、痰量、痰黏度、喘息总有效率（92．0％、94．0％、90．0％、90．0％）高于B组（80．0％、86．0％、80．0％、78．0％）（X^2=3．991，x^2=4．012，x^2=3．998，x^2=3．971，均P〈0．05）；A组6例不良反应（12．0％）B组7例不良反应（14．0％）（x^2=1．971，P〉0．05）。结论复方磷酸可待因糖浆联用氨溴索治疗稳定期慢性阻塞性肺病疗效肯定、安全性好。
Objective To investigate the effect and safety of Compound codeine phosphate syrup with Ambroxol treatment in the stable phase of chronic obstructive pulmonary disease. Methods 100 patients with stable COPD were divided into Compound codeine phosphate syrup with Ambroxoh treatment group （ Group A） 50 eases and Compound codeine phosphate syrup treatment group（ Group B） 50 cases,drug were given for 3 - 7d. The symptom score and efficacy of two groups before treatment and after treatment were compared. Results The symptom score of cough, sputum volume, sputum viscosity, wheeze, sleep after treatment 8th day were improved significandy （X^2=3.891,X^2=3.992,x^2=4.198,x^2=3.981,X^2=3.879, allP 〈 0. 05 ; Total effective rate of cough, sputum volume, sputum viscosity,wheeze in group A（92. 0% ,94.0% ,90. 0% ,90.0% ） higher than that in group B（80.0% ,86.0% ,80. 0%, 78. 0% ） （x^2 =3.991 ,X^2 =4. 012,X^2 = 3. 998,X^2 = 3.971 ,allP 〈0. 05） ;The adverse reactions of A,B group were 12. 0% and 14. 0% （ X^2 = 1. 971,P 〉 0. 05 ）. Condusion Compound codeine phosphate syrup with Ambroxol is an effective and safe antitussive in the stable phase of chronic obstructive pulmonary disease.
出处
《中国基层医药》
CAS
2010年第6期721-722,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
复方磷酸可待因糖浆
氨溴索
慢性阻塞性肺疾病
稳定期
Compound codeine phosphate syrup
Ambroxol
Chronic obstructive pulmonary disease, Stable phase
