摘要
目的：探讨脑脉舒宁降压作用的机理。方法：采用大鼠胸主动脉条测定脑脉舒宁对去甲肾上腺素（ＮＥ）、ＣａＣｌ２的量效曲线以及对单剂量氯化钾所致收缩的影响。结果：脑脉舒宁能使ＮＥ、ＣａＣｌ２的量效曲线右移，最大反应压低，呈非竞争性拮抗；同时也可抑制高钾去极化引起的血管条收缩。结论：脑脉舒宁松弛血管平滑肌的作用与拮抗Ｃａ２＋有关。
Objective: To explore the mechanism blood lowering effect of Naomaishuning.Methods: The effect of Naomaishuning on the contraction isolated rat aortic strips induced by calcium,norepinephrine and potassium.Results: The results showed that Naomaishuning shifted the cumulative concentration response curves for CaCl 2 and norepinephrine to right,and depressed their maximal responses.It appeared that the Naomaishuning was noncompetitive antagonist to CaCl 2 and norepinephrine,Naomaishuning also inhibited the contration of aortic strips evoked by single dose of KCl.Conclusion:The results suggested that Naomaishuning block calcium channels.
出处
《河南医学研究》
CAS
1999年第1期11-12,共2页
Henan Medical Research
基金
河南省科委资助
关键词
胸主动脉条
脑脉舒宁
降压
中药药理
aortic strip
calcium
norepinephine
potassium
Naomaishuning
