摘要
目的:研究二恶英(TCDD)对于小鼠学习记忆功能的影响。方法:将48只雌雄各半的昆明种小鼠按性别随机分为高、中、低剂量染毒组和对照组,每组6只,染毒剂量分别为100μg/kg体重、10μg/kg体重、1μg/kg体重,用腹腔注射的方式一次染毒,24 h和48 h后进行跳台实验,记录小鼠首次跳下的潜伏期和跳下的错误次数。结果:与对照组相比,雄性小鼠中高剂量组的记忆潜伏期显著增加(P<0.05),在记忆功能实验中,雌性小鼠低、高剂量染毒组中小鼠跳下平台的错误次数显著增加(P<0.05)。结论:二恶英对小鼠的学习记忆功能有一定的影响,且存在性别差异。
Objectives：To assess the effect of TCDD on the learning and memorial function of mice.Methods： 24 male mice and 24 female mice were randomly divided into four groups according to the sex：high dose（100 μg/kg） groμp,middle dose（10 μk/kg） group,low dose（1 μg/kg）group and the control group.Each group has 6 mice.The mice were injected ip with TCDD（controls were injected ip with DMSO）.After 24 hours and 48 hours,the step-down test was performed to evaluate the learning and memorial function of the mice.Results： Compared with the controls,there was a significant increase in the memorial latent time of the male mice（P〈0.05） from the high-dose group and the wrong step down times was significantly increased in the female rats with low and high dose of TCDD（P〈0.05）.Conclusions： TCDD has certain effects on the learning and memorial function of mice,with some differences between male and female mice.
出处
《包头医学院学报》
CAS
2010年第2期14-15,31,共3页
Journal of Baotou Medical College
关键词
二恶英
学习记忆功能
跳台实验
2
3
7
8-tetrachlorodibenzo-p-dioxin（TCDD）
Learning and memorial function
Step-down test
