摘要
目的观察安替可胶囊（ａｎｔｉｋｅ）对荷人癌裸鼠的抑瘤作用及其治疗晚期消化道肿瘤的疗效．方法采用ＭＴＴ和人癌细胞克隆形成以及裸鼠荷瘤技术；临床上晚期消化系癌５３２例，其中Ⅱ期１１１例，占２０９％；Ⅲ期２２２例，占４１７％；Ⅳ期１９９例，占３７４％；均经病理证实，全部病例采用数表法随机分组．结果人癌细胞对ａｎｔｉｋｅ的敏感性顺序依次是：Ｍｇｃ８０３≥Ｅｃａ１０９＞ＳＭＭＣ７７２１；Ａｎｔｉｋｅ５００ｍｇ／ｋｇ对Ｍｇｃ８０３，Ｅｃａ１０９和ＳＭＭＣ７７２１人癌细胞裸鼠的瘤重抑制率分别为４７２％，４７２％和４５４％；Ａｎｔｉｋｅ治疗晚期食管癌、肝癌和肠癌２５８例，总缓解率（ＣＲ＋ＰＲ）为７４％，并能显著止痛，改善生存质量和提高免疫功能；放疗＋ａｎｔｉｋｅ治疗晚期食管癌１００例，总缓解率为７２０％，比单纯放疗组（３４４％）提高了３７６％（Ｐ＜００１），同时，能显著改善吞咽困难，明显增加体重，保护血象和降低ＣＥＡ．结论Ｍｇｃ８０３，Ｅｃａ１０９和ＳＭＭＣ７７２１对ａｎｔｉｋｅ较敏感，并且ａｎｔｉｋｅ对其裸鼠移植瘤具有明显抑制作用；Ａｎｔｉｋｅ对食管癌、胃癌、肝癌有较好疗效。
AIM To observe the inhibitory effect of Chinese herbs antike to human cancer cells, nude mice transplantation tumor and the short term effect on advanced malignant tumor of digestive tract. METHODS MTT and human cancer cells clone formation as well as nude mice transplantation tumor model were used in this experiment. Advanced GI tract tumour patients ( n =532; stage Ⅱ, n =111, 20 9%; stage Ⅲ, n =222, 41 7%; stage Ⅳ, n =199, 37 4%) were grouped according to random number table. RESULTS Sensitivity of human cancer cells to antike in order was: Mgc 803 ≥Eca 109 >SMMC 7721 ; Inhibition rates of 500mg/kg antike to Mgc 803 , Eca 109 and SMMC 7721 human cancer cells were 47 2%, 47 2% and 45 4% respectively; The total remission rate (CR+PR) of antike for 258 cases of esophageal, hepatic, gastric and intestinal carcinomas of late stage was 7 4%.Antike had marked analgesic action, and could improve the life qualities and body immunefunction. The total remission rate by combination of radiotherapy and antike for 100 cases of advanced esophageal carcinoma reached 72 0%, compared with simple radiotherapy (34 4%),the improvement was significant (37.6%,P<0.01). The patients' dysphagia was improved obvious ( P <0 05), body weight increased, hemogram protected and CEA decreased. CONCLUSION Mgc 803 , Eca 109 and SMMC 7721 are sensitive to antike. Antike has obviously inhibitory effect on nude mice transplantation tumor. Human esophageal carcinoma, gastric carcinoma and hepatic carcinoma respond well to antike, and antike also can enhance radiation sensitivity remarkably.
出处
《世界华人消化杂志》
CAS
1999年第3期236-239,共4页
World Chinese Journal of Digestology
关键词
消化系统肿瘤
药物疗法
安替可胶囊
晚期
疗效
digestive system neoplasms/drug therapy
esophageal neoplasms/drug therapy
stomach neoplasms/drug therapy
