摘要
目的：提高肾移植术后的长期存活率。方法：收集手术切除的无功能移植肾病理标本作为实验组；其相应的肾移植术前活检组织作为对照组。采用自身前后对照，从常规病理、免疫组化、透射电镜等方面，研究移植肾排斥反应、细胞凋亡及Ｂｃｌ－２表达的病理学改变。结果：Ｂｃｌ－２染色可显示存活的肾小管，排斥反应破坏肾小管，Ｂｃｌ－２保护肾小管生存。
Objective: In order to improve the long term survival of renal allograft, a study on rejection and expression of Bcl 2 in renal allografts was designed in this series. Methods:Immunohistochemical determination using antibodies for Bcl 2 gene protein were performed in 6 cases of acute rejection, 3 cases of chronic rejection, and 1 case of cytomegalovirus infection. Two cases of acute rejection and two cases of chronic rejection were studied by transmission electron microscope to confirm apoptosis. Results:On the tubules stain for Bcl 2, it showed that a more positive density was found in control group comparing with allografts ( P <0.01). Under electron microscope, apoptosis were demonstrated. Conclusion:Detection and localization Bcl 2 expression may act as morphological characteristics to monitor the renal allograft.
出处
《军医进修学院学报》
CAS
1999年第1期29-31,共3页
Academic Journal of Pla Postgraduate Medical School
