摘要
目的:观察凉血活血颗粒对放射性肺损伤大鼠凝血功能及全血黏度的影响。方法:90只雄性Wistar大鼠,随机分为空白对照组、模型组、凉血活血颗粒治疗组,每组30只,模型组及治疗组大鼠用6MVX线右胸一次性照射25Gy造模。造模前1周开始各组分别ig凉血活血颗粒或生理盐水,每日1次。在照射后7d,30d,90d,每组处死10只,行肺组织HE染色,腹主动脉取抗凝血检测凝血4项及全血黏度指标。结果:模型组照射后出现放射性肺炎及纤维化表现,治疗组炎症及纤维化表现较模型组明显减轻。模型组大鼠在照射后7d,出现高凝、高黏改变;在放射后30d,出现低凝、低黏改变;在放射后90d出现低凝、高黏改变。治疗组大鼠在照射后7d,凝血时间延长,血液黏度减低;在照射后30d,凝血时间缩短,血液黏度升高;在放射后90d,凝血时间缩短,全血黏度降低。结论:放射性肺损伤存在凝血功能紊乱及血液黏度异常,凉血活血颗粒对上述情况具有调节作用,能减轻放射性肺损伤的严重程度。
Objective：To object the influence of a Chinese herbal compound granule with functions of cooling and promoting blood circulation on coagulation function and whole blood viscosity in rats with radiationinduced lung injury. Method：Ninety male wistar rats were randomly assigned to blank group,model group and treatment group with 30 rats in each group. The rats in model and treatment group were irradiated with 6 MV x-rays, 25Gy /fraction in the right lung and were given saline or Chinese herbal compound granule accordingly. The rats in blank group were given saline without radiation. Ten rats in each group were sacrificed at the time of 7 d,30 d and 90 d after radiation. The tissue pathology was conducted; Whole blood viscosity and coagulation indexes were evaluated. Result：The rats in model group developed radiation pneumonitis and fibrosis. The pathological changes of radiation injury in treatment group were slighter than the model group. The rats in model group were in the high coagulation and viscosity state in 7 d,in the low coagulation and viscosity state in 30 d,in the low coagulation and high viscosity state in 90 d. The coagulation time in the treatment group was longer in 7 d,shorter in 30 d and 90 d;The whole blood viscosity was decreased in 7 d,increased in 30 d,decreased in 90 d. Conclusion： Blood coagulation function disorder and viscosity abnormality occurred in the radiation-induced lung injury. The herbal compound granule with functions of cooling and promoting blood circulation can make appropriate adjustment and reduce the radiation-induced lung injury.
出处
《中国实验方剂学杂志》
CAS
北大核心
2010年第5期103-106,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(3037l826)
军队"十一五"计划项目(06MA251)
关键词
放射性肺损伤
中医药
凉血活血
全血黏度
radiation-induced lung injury
Chinese herbal medicine
blood cooling and promoting
whole blood viscosity
