摘要
目的探讨麝香保心丸对心肌梗死后慢性心力衰竭大鼠血浆内皮素1(ET-1)和肾上腺髓质素(ADM)水平的影响。方法 80只Wistar大鼠随机分为正常对照组(A组,10只)、假手术组(B组,10只)、其余60只制作心力衰竭模型,将制模成功35只大鼠又分对照组(C组,9只)、麝香保心丸小剂量组(D组,9只)、麝香保心丸大剂量组(E组,9只)和阳性药物对照组(F组,8只),采用灌胃法给药。超声心动图检测用药前后大鼠心脏功能,放射免疫法检测ET-1、ADM水平。结果 A组与B组用药前LVEF、左心室舒张末内径(LVEDD)、左心室收缩末内径(LVESD)无显著差异。与B组用药前比较,C组、D组、E组、F组大鼠LVEF明显降低,LVEDD、LVESD明显增加(P<0.01);与C组用药后比较,E组大鼠LVEF明显升高,LVEDD、LVESD明显减小(P<0.05),D组、F组LVESD明显减小(P<0.05);与B组比较,C组大鼠ET-1、ADM水平明显升高(P<0.05,P<0.01);与C组比较,D组、E组、F组大鼠ET-1水平明显降低(P<0.05,P<0.01),E组ADM水平明显降低(P<0.01)。结论麝香保心丸可能通过改善心肌血供,进而抑制慢性心力衰竭时神经内分泌系统的激活,并起到了有效治疗作用。
Objectives To investigate the effects of Shexiangbaoxin pills（SXBXP） on the plasma levels of endothelin-1 （ET-1） and adrenomedullin （ADM） in rats with chronic heart failure （CHF）. Methods Models of CHF were established by anterior descending coronary artery liga- tion. Fifty-four Wistar rats were randomly divided into six groups： control group（group A, n 10） ,sham operation group（group B, n = 10）,CHF model group（group C, n = 8）, small-dose SXBXP group（group D, n = 9） ,large-dose SXBXP group（group E, n = 9） and positive medicine group（group F, n ^- 8）. Heart function was examined by echocardiography before and after thera- py,plasma ET-1 and ADM levels were measured by radioimmunoassay. Results Compared with group I3 before therapy,the ejection faction of left ventricle（LVEF） of groups C,D,E,F was sig- nificantly decreased （P 〈 0. 01） , after therapy,plasma levels of ET-1 and ADM of group C were markedly increased （P 〈0.05, P 〈 0.01）. Compared with group C, LVEF of group E was signifi- cantly improved （P 〈 0.05） ,plasma levels of ET-1 and ADM of group E were markedly decreased （P〈 0.01） ,plasma levels of ET-1 in groups D and F were significantly decreased （P 〈 0.05）, LVEF and plasma levels of ADM of groups D and F decreased. Conclusions Heart function was ameliorated by SXBXP therapy in rats with CHF. The therapeutical effect of SXBXP may be re- lated to better blood supply for myocardium and inhibition of neuroendocrine activation.
出处
《中华老年心脑血管病杂志》
CAS
北大核心
2010年第5期448-451,共4页
Chinese Journal of Geriatric Heart,Brain and Vessel Diseases
基金
中国中西医结合学会科研基金(2008-01)
