摘要
目的:观察益气软肝汤的抗肝纤维化作用。方法:用日本血吸虫尾蚴感染新西兰免,制成肝纤维化模型,病兔均予吡喹酮顿服杀虫治疗,继之中药组开始服用益气软肝汤治疗肝纤维化,并与γ-干扰素组及生理盐水组比较,观察活化的肝星状细胞(HSC)被α-SMA染色后的阳性表达情况,以及肝胶原沉积情况,并判断肝纤维化程度。结果:中药组、干扰素组的肝纤维化程度及α-SMA阳性细胞表达情况均显著轻于生理盐水组(P<0.05),3组的抗纤效果以干扰素组为最佳,中药组次之,生理盐水组无效(各组间比较P<0.05)。结论:益气软肝汤具有较好的抗血吸虫病肝纤维化作用。
Aim: To observe the anti-hepatofibrosis effect of Yiqi Ruangan Decoction (YQRGD) in rabbits infected with schistosoma japonicum. Method: Rabbit models of liver fibrosis were obtained by intfection of schistosoma japon-icum. After being treated with Praziquantel, the rabbits were divided into three groups: the first group was treated with gammainterferon(γ-IFN),the second with YQRGD,and the third with normal saline, which used as control. The activation of hepatic stellate cells (HSC) was observed by α-SMA stain and the the degree of liver fibrosis was measured with collagen deposition on liver. Results: α-SMA positive cells and the degree of liver fibrosis in YQRGD were significantly lower than that of the control group(P<0. 05). Conclusion :The results showed that YQRGD had the anti-hepatofibrosis effect on experimental rabbits.
出处
《中西医结合肝病杂志》
CAS
1999年第1期24-25,共2页
Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases
基金
浙江省地方病防治办公室资助课题
关键词
益气软肝汤
血吸虫病
肝纤维化
防治
Yiqi Ruangan Decoction Schistosomiasis Hepatic Fibrosis HSC
