摘要
目的:探讨2型糖尿病患者血尿酸水平和肾脏白蛋白排泄率的关系。方法:检测316例2型糖尿病患者血尿酸、晨尿微量白蛋白/肌酐、尿酸排泄分数,根据尿微量白蛋白/肌酐水平分为正常组、微量白蛋白组和大量白蛋白组,根据血尿酸水平分为尿酸正常组(血尿酸<360μmol/L)和高尿酸血症组(血尿酸≥360μmol/L),将患者血尿酸水平从低到高排序,等分为4组,使用SPSS 13.0软件包进行分析。结果:(1)高尿酸血症组体质量指数、腰臀比、平均动脉压、三酰甘油及尿微量白蛋白/肌酐较尿酸正常组高(P<0.05)。(2)正常组、微量白蛋白组、大量白蛋白组血尿酸水平分别为(285.3±76.8)μmol/L、(300.1±101.3)μmol/L、(342.4±103.8)μmol/L,组间比较差异有统计学意义(P<0.05);血尿酸值等分4组的异常尿白蛋白患病率分别是19.4%,20.0%,22.5%,34.8%。(3)以尿微量白蛋白/肌酐为因变量进行多元逐步线性回归,血尿酸、尿酸排泄分数及平均动脉压进入方程,以尿微量白蛋白/肌酐分级为因变量进行二元logistic回归,结果显示血尿酸的相对危险度为1.158,P=0.008。结论:2型糖尿病患者血尿酸与肾脏白蛋白排泄率独立相关,可反映肾脏的早期病变。
Objective To explore the correlation between serum uric acid and urinary albumin to creatinine ratio in patients with type 2 diabetes mellitus.Methods A total of 316 patients with type 2 diabetes mellitus were detected serum uric acid,fractional excretion of uric acid and urinary albumin to creatinine ratio.The patients were divided into normal albuminuria,microalbuminuria and macroalbuminuria group according to urinary albumin to creatinine ratio,and normal groups（SUA〈360 μmol/L） and hyperuricemia group（SUA≥360 μmol/L） according to serum uric acid level.All patients were redivided into 4 groups according to the serum uric acid levels.SPSS 13.0 software package was used to do the analysis.Results Hyperuricemia groups had higher body mass index,waist to hip ratio,mean arterial pressure,triacylglycerol and urinary albumin to creatinine ratio（P〈0.05）.The serum uric acid levels of normal albuminuria group,microalbuminuria group,and macroalbuminuria group were（285.3±76.8）,（300.1±101.3） and（342.4±103.8） μmol/L respectively,which showed a statistic difference（P〈0.05）.The prevalence of abnormal albuminuria of the 4 groups were 19.4%,20%,22.5% and 34.8%.The serum uric acid,fractional excretion of uric acid,and the mean arterial pressure were the independent risk factors of urinary albumin to creatinine ratio,and the odds ratio of serum uric acid for abnormal albuminuria was 1.158（P=0.008）.Conclusion The serum uric acid is independently associated with urinary albumin to creatinine ratio in type 2 diabetes mellitus,and can reflect the nephropathy in the early stage.
出处
《中华实用诊断与治疗杂志》
2010年第5期452-454,共3页
Journal of Chinese Practical Diagnosis and Therapy
关键词
2型糖尿病
血尿酸
尿微量白蛋白肌酐比值
尿酸排泄分数
Type 2 diabetes mellitus
serum uric acid
urinary albumin to creatinine ratio
fractional excretion of uric acid
