摘要
目的研究大豆异黄酮对人体抗氧化能力的影响。方法选择年龄在45～65岁的健康志愿者116人,根据SOD、GSH-Px活性和MDA含量,随机分为观察组和安慰剂对照组,每组58人,试食组每天口服大豆异黄酮软胶囊2 g,连服3个月,对照组服用安慰剂。试食前后对每位受试者进行相关安全性指标及SOD、GSH-Px、MDA三项功效指标测定。结果试食前后各项安全性指标均在正常范围内,且未发现明显不良反应。试食后观察组SOD、GSH-Px活力分别较试食前提高11.5%、5.2%,MDA降低15.6%。试食后观察组SOD、GSH-Px和MDA活力与对照组比较,差异均有统计学意义。结论本试验条件下,大豆异黄酮对人体安全且具有抗氧化作用。
Objective To study the anti-oxidative effect of soybean isoflavone（SI） in human.Methods 116 healthy volunteers aged from 45 to 65 were randomly divided into two groups：the placebo-controlled group and the SI-treated group in accordance with superoxide dismutase（superoxide dismutase,SOD）,glutathione peroxidase（glutathione peroxidase,GSH-Px） activity and malondialdehyde（maleic dialdehyde,MDA） content.The SI capsule was administered to the SI-treated group 2 g/d orally for 3 months,while placebo was administered to the control group.Before and after the test,determination was carried for subjects on each relevant safety indicators and SOD,GSH-Px,MDA.Results Results of the targets on food safety parameters were within normal range before and after the trial,and obvious adverse reactions were not found.The SOD and GSH-Px levels were significantly higher after the trial in the SI-treated group than before,i.e.increased by 11.5%,5.2% respectively,while the MDA level was significantly lower,15.6% in the SI-treated group than before.Conclusions For human,SI is safe and has a significant anti-oxidative effect in vivo.
出处
《公共卫生与预防医学》
2010年第2期25-28,共4页
Journal of Public Health and Preventive Medicine
关键词
大豆异黄酮
人体服食
安全性
抗氧化功能
Soybean isoflavones（SI）
Clinical trail
Safety
Anti-oxidation function
