摘要
6-(bromomethyl)-2-methylquinazolin-4(3H)-one is the important intermediate which is first-line drugs for treating colon and rectal cancers.In order to investigate the Raltitrexed better,to optimizeby production method,we designed a synthetic route based related literature by cycling,ammoniation and bromination.The process provided high yield,synthetic methodology.The yield of 6-(bromomethyl)-2-methylquinazolin-4(3H)-one was up to 64.8%
6-（bromomethyl）-2-methylquinazolin-4（3H）-one is the important intermediate which is first-line drugs for treating colon and rectal cancers.In order to investigate the Raltitrexed better,to optimizeby production method,we designed a synthetic route based related literature by cycling,ammoniation and bromination.The process provided high yield,synthetic methodology.The yield of 6-（bromomethyl）-2-methylquinazolin-4（3H）-one was up to 64.8%
出处
《化学研究与应用》
CAS
CSCD
北大核心
2010年第5期609-612,共4页
Chemical Research and Application
