摘要
目的了解酒精对雄性大鼠睾丸生精功能及血清睾酮(T)、黄体生成素(LH)、卵泡刺激素(FSH)的影响,探讨酒精对生殖系统的毒性作用。方法将30只雄性大鼠随机分成2组,酒精组用人类饮用白酒经口灌胃,2mL/d,每天1次;对照组用蒸馏水以同样方法灌胃,连续28d。末次灌胃24h后处死取材。结果酒精组雄性大鼠体重明显低于对照组(P<0.05)。酒精组雄性大鼠血清中T、LH及FSH水平均较对照组低(P<0.05);酒精组雄性大鼠精子数量、活动率、精子活力均低于对照组(P<0.05),精子畸形率高于对照组(P<0.05);组织学观察显示酒精组曲精小管萎缩变细,精细胞排列紊乱疏松,生精细胞变性、坏死、脱落。结论酒精对雄性大鼠生殖系统有明显的毒性作用,一方面直接作用于睾丸,抑制精子发生和睾酮合成,另一方面还使下丘脑-垂体轴生殖内分泌功能受损。减少饮酒对优生有重要意义。
Objective To probe into the effect of alcohol on the scrotum reconstruction and serum testosterone （T）,luteinizing hormone （LH） and follicle stimulating hormone （FSH） of male rats.To explore the alcohol＇s toxicity to reproduction.Method 30 male rats were divided into 2 groups at random,and the alcohol group were irrigated the stomach with alcohol through the mouth,2 mL a day,while the control group with distilled water for 28 days continuously.At the last time,the rats were put to death 24 hours after irrigation.Results The weight of the male rats in the alcohol group was obviously lighter than that in the control group（P〈0.05）.The T,LH and FSH of the male rats in the alcohol group were lower than those in the control group（P〈0.05）.The sperm quantity,activity ratio and the sperm vigor of the male rats in the alcohol group were obviously lower than those in the control group（P〈0.05）.The sperm deformity was obviously higher than that in the control group（P〈0.05）.Microanatomy observation demonstrates that there was tubule atrophy,spermatid arrangement chaos and unprocessed spermatid degeneration,necrosis and abscission.Conclusion Alcohol produces an obvious poisonous effect on the reproductive system of male rats.On the one hand,it acts on testiculus directly,restraining sperm occurrence and testosterone combining.On the other,it damages the endocrine function of the hypothalamus-hypophysis system.Therefore,less alcohol drinking is of great significance to aristogenesis.
出处
《保健医学研究与实践》
2010年第2期4-6,共3页
Health Medicine Research and Practice
关键词
酒精
大鼠
生殖系统
Alcohol
Rat
Reproductive system
