摘要
目的制备西罗莫司缓释片并对其释药因素进行考察。方法采用羟丙基甲基纤维素(HPMC)为基本骨架材料制备了西罗莫司凝胶骨架片,对影响释药的因素,如采用羟丙基甲基纤维素(HPMC)规格、用量、填充剂种类、致孔剂用量、压片压力及释放介质等进行了考察。结果以30%羟丙基甲基纤维素(HPMC K4M)为骨架材料、2%乳糖为致孔剂、微晶纤维素(MCC)为填充剂时,缓释片呈明显一级释放特征。结论该制剂在体外具有良好的缓释效果,且制备工艺简单易行。
Objective To prepare the sirolimus sustained-release tablets and study the influence factor.Methods The sirolimus sustained-release tablets were prepared by HPMC as the matrix material.The effects of viscosity of HPMC,sort of an adhensive amount of a lubricant,and the preparation methods on the release of sirolimus from matrix tablets were observed.Results Based on the results of single factor tests,an optimal self-prepared matrix sustsained-release tablets which contained 30 % HPMC（K4M）,2 % lactose and MCC was definited.The release of the drug was an obvious characteristic in first class.Conclusion The tables have desirable sustain-release property in vitro.The preparation process was simple and can be applied in production.
出处
《药学实践杂志》
CAS
2010年第2期126-129,139,共5页
Journal of Pharmaceutical Practice
基金
福建省科技计划项目(2007Y0063)
