摘要
目的比较阿仑膦酸钠(ALN)单用或联合钙剂治疗对维甲酸所致实验性骨质疏松大鼠的防治效果,为临床治疗骨质疏松用药方案的选择提供依据。方法维甲酸灌胃诱发大鼠骨质疏松模型,ALN或ALN+钙剂每天灌胃给药,比较两种治疗方案对骨质疏松大鼠体质量、血磷、血钙、碱性磷酸酶(ALP)、骨密度(BMD)和骨组织形态学的影响。结果ALN单用或联合钙剂治疗均可提高骨质疏松大鼠的血磷水平和骨密度,降低升高的血钙和ALP水平,改善其病理改变,联合用药的作用稍优于单独用药。结论ALN有明确的治疗骨质疏松的作用。骨质疏松发生后,采用几种药物的联合应用是比较合理的治疗方案。
Objective To compare the clinical effect in treating osteoporosis（OP） rats with alendronate（ALN） alone or combined with calcium in experimental Osteoporosis rats,and to provide evidence for the therapeutic choice.Methods Rat models of OP were induced by retinoic acid.One group rats were given ALN by intragastric once a week for 28 days.The other group rats were given ALN by intragastric once a week and calcium one times per day for 28 days.Observed and compared the result of both treatments effect the body weight,the level of serum calcium,phosphorus,alkaline phosphatase（ALP） and bone mineral density（BMD） and the tissue histopathological femur.Results Both ALN alone or combined with calcium significantly increased serum phosphorus and BMD,decreased the serum level of calcium and ALP of OP rats.The bone tissue histopathological was improved.The combined use of ALN and calcium is slightly better than the using ALN alone.Conclusion ALN has therapeutic effect on osteoporosis rats.The combined use of anti-osteoporosis medications drugs is the better choice.
出处
《安徽医学》
2010年第4期310-312,共3页
Anhui Medical Journal
基金
广东省深圳市科技计划项目(200703221)
