摘要
目的研究原发性高血压(EH)伴阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与左心室结构改变的关系并分析其影响因素。方法对2004-07-2007-07住院的EH患者进行睡眠监测,并对其一般资料、生化指标、超声心动图检查结果进行分析,比较EH+OSAHS与EH患者间左心室构型的差异,观察其影响因素。结果EH+OSAHS组年龄、男性比例、体质量指数、收缩压、空腹及餐后2 h血糖均高于EH组(均P<0.01);EH+OSAHS组的左室舒张期内径、室间隔厚度、左室后壁厚度、左室质量指数、相对室壁厚度均高于EH组(均P<0.01);与左心室肥厚发生相关的危险因素为OSAHS、高血压病程、血压分级、糖尿病、肾功能不全。结论与EH相比,EH+OSAHS左心室构型改变更严重。
Objective To examine whether obstructive sleep apnea-hypopnea syndrome（OSAHS） is associated with left ventricular structural abnormalities in hypertensive patients.Methods Portable polysomnography,echocardiography and laboratory testing were performed in 569 consecutive subjects from the department of hypertension,Ruijin Hospital from July,2004 to July,2007.Difference of left ventricular structure was compared between patients with and without OSAHS.Results The age,proportion of gender,body mass index,systolic blood pressure,the levels of fasting blood glucose and 2 h postprandial blood glucose were significantly higher in subjects with OSAHS compared with those without OSAHS（P〈0.01）.LVDd,LVST,PWT,LVMI and RWT were significantly greater in those with OSAHS than in those without OSAHS（P〈0.01）.The risk factors of left ventricular hypertrophy were OSAHS,the duration and the level of hypertension,diabetes and renal impairment.Conclusion Hypertensive patients with OSAHS have more prominent ventricular hypertrophy compared with those without OSAHS.
出处
《中华高血压杂志》
CAS
CSCD
北大核心
2010年第4期349-352,共4页
Chinese Journal of Hypertension
基金
上海市卫生局基金(054043)上海市教委基金(05BZ09)
"十一五"国家科技支撑计划项目(2006BAI01A03)子课题
