摘要
目的探讨预先静脉注射帕瑞昔布钠对术后患者自控静脉镇痛(PCIA)的影响。方法60例择期下肢骨折内固定取出术患者随机均分成三组,Ⅰ组于切皮前30min静注帕瑞昔布钠40mg,Ⅱ组缝皮结束时静注帕瑞昔布钠40mg;Ⅲ组不用帕瑞昔布钠。三组术毕均用芬太尼PCIA。记录术后8、24、48h的VAS评分及术后24h内芬太尼用量及其不良反应。结果三组术后镇痛效果均满意。术后8、24hVAS评分:Ⅰ组明显小于Ⅱ组(P<0.05);Ⅲ组明显大于Ⅱ组(P<0.05)。术后24h内芬太尼用量Ⅰ组(0.30±0.07)mg、Ⅱ组(0.34±0.09)mg,明显少于Ⅲ组的(0.43±0.08)mg(P<0.05)。三组间不良反应无明显差异。结论术前预先静脉内注射帕瑞昔布钠在一定程度上能增强术后镇痛效果、减少术后镇痛芬太尼用量。
Objective To study the effect of patient-controlled intravenous analgesia（PCIA） with fentanyl.Methods Sixty patients undergoing the removal of internal fixation of the lower extremity were randomized to three groups with 20 cases each.The patients in groupⅠwere injected intravenously parecoxib sodium 40 mg 30 min before operation,which was given at the end of operation in group Ⅱ.The patients in group Ⅲ were not given as the controls.All patients received PICA with fentanyl.The analgesic effect was observed by VAS at 8,24,and 48 h after surgery.The fentanyl consumption and adverse responses were recorded as well.Results Analgesia was satisfectory in all cases.VAS points at 8 and 24 h after operation were significantly lower in groupⅠ than those in group Ⅱ（P0.05）,which were all lower than those in group Ⅲ（P0.05）.The consumption of fentanyl of group Ⅲ was significantly greater than that in group Ⅰ or group Ⅱ ／[（0.43±0.08） mg vs.（0.30±0.07） mg or （0.34±0.09） mg／] （P0.05）.There was no significant difference in adverse responses among three groups during analgesia.Conclusion Preoperative injection of parecoxib sodium may improve the outcomes of PCIA with fentanyl and reduce comsumption of fentanyl in the patients underwent removal of internal fixation.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第6期659-661,共3页
Jiangsu Medical Journal
关键词
帕瑞昔布钠
术后镇痛
Parecoxib sodium
Postoperative analgesia
