摘要
目的探讨创伤早期促血管生成素-2（Ang-2）的变化及临床意义。方法遴选20～60岁、伤后1h内就诊入院的多发伤患者45例，按损伤严重度评分（ISS）分为3组，人院后立即采血，对比分析各组血浆Ang-2、TNF-α、IL-6含量变化。同时，观察临床指标，对比分析不同氧合指数、休克指数和碱缺失状况下的血浆Ang-2含量变化。结果血浆Ang-2与ISS评分呈正相关（r=0．878，P〈0．01），与炎症因子TNF-α、IL-6变化具有高度的一致性（r=0．720，r=0．758，P〈0．01）；休克指数增加或氧合指数下降时，血浆Ang-2值硅著升高（P〈0．01）；碱缺失升高，血浆Ang-2值也随之显著升高（P〈0．01）。结论Ang-2是创伤后早期出现内皮激活和机能失调的重要标志，与炎症介质释放和组织氧合灌注密切相关，可能与创伤后病情进展和预后密切相关。
Objective To investigate early changes of angiopoietin-2 （Ang-2） in multiple trauma patients and assess its clinical significance. Methods Forty-five muhiple trauma patients aged 20- 60 years admitted to the hospital within one hour after injury were randomly divided into three groups cording to injury severity score （ISS）. Blood specimens were obtained immediately upon arrival in the e- mergency department and plasma samples were assayed for comparing changes of Ang-2, TNF-α and IL-6. Meanwhile, plasma level of Ang-2 was measured and analyzed under different oxygenation index, shock index and base deficit. Results Plasma level of Ang-2 was positively correlated with ISS （P 〈 0.01 ） and was concordant with the plasma levels of TNF-α and IL-6 （P 〈0.01 ）. Furthermore, plasma level of Ang-2 was elevated upon increase of shock index or decrease of oxygenation index （ P 〈 0.01 ）. Plasma level of Ang-2 was elevated with the increase of base deficit （ P 〈 0.01 ）. Conclusions High level of Ang-2 is a marker of endothelial activation and dysfunction early after trauma. Ang-2 is related tightly with the injury severity, inflammation factors, systemic oxygenation and tissue hypoperfusion and may have a tight relation with pathophysiological development and clinical outcome after trauma.
出处
《中华创伤杂志》
CAS
CSCD
北大核心
2010年第4期328-331,共4页
Chinese Journal of Trauma
基金
创伤、烧伤与复合伤国家重点实验室开放基金资助项目（2007-A-6）
