摘要
通过将渗出型年龄相关性黄斑变性（age-relatedmaculardegeneration，AMD）患者黄斑区OCT形态学检查及视觉电生理视功能检查相结合，探讨渗出型AMD的形态学改变与视功能改变之间的相互关系。方法选取初次诊断为年龄相关性渗出型AMD的患者渗出组20例（30只眼）以及同年龄段正常对照组15名（30只眼），根据眼底及荧光造影检查将渗出组仅发生玻璃膜疣和脉络膜新生血管膜（CNV）的12只眼归为早期渗出组，并发视网膜下出血及渗出的18只眼归为渗出期组。对三组病人进行黄斑中心凹OCT检查及眼电生理检查。采用单因素方差分析检查结果。结果（1）黄斑中心凹水平及垂直神经上皮层厚度：早期渗出组较正常组明显增厚（P〈0．05）；渗出期组较正常组和早期渗出组明显增厚（P〈0．05）。（2）眼电生理检查结果：暗适应ERG，OPS振荡电位以及P—VEP的检查结果表明，早期渗出组已出现了明显的视功能损害；渗出期组的视功能受损较早期渗出组严重。结论渗出型AMD患者视功能的改变合并有视网膜神经上皮层的变厚，渗出期患者的黄斑区形态以及视网膜功能的改变比渗出早期更严重。
Objective To investigate the relation between configuration and visual function ofmacular region on exudative age-related maeular degeneration （AMD）. Methods OCT and visual electrophysiological examination were used in 30 eyes of 15 healthy volunteers and 30 eyes of 20 exudative AMD patients. Patients with exudative AMD were divided into pre-exudative group and exudative group .Results 1.The results of OCT showed that, the thickness of retinal neurepithelium layer （in macular region） in the pre-exudarive group was significantly thicker than that in the normal group （P〈0.05） ; and it was also significantly thicker in the exudative group than that in the other groups （P〈0.05）.2.The results of visual electrophysiologieal examination revealed that visual function injury happened in the pre-exudative group, and it was more severe in the exudative AMD group than that in the pre-exudative group.Conclutions In exudative AMD, we found the damage of visual function is accompanied by the change of retinal neurepithelium layer＇ s thickness in macular region.The functional damage of vision and the retinal neurepithelium layer＇ s swelling in the exudative group are more serious than that in the pre-exudative group.
出处
《中国实用眼科杂志》
CSCD
北大核心
2010年第4期327-330,共4页
Chinese Journal of Practical Ophthalmology
关键词
渗出型年龄相关性黄斑变性
光学相干断层扫描
眼电生理检查
Exudative age-related macular degeneration
Visual coherence tomography
Visual electrophysiological examination
