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MV3恶性黑素瘤皮肤体外模型中基质金属蛋白酶－2、9的表达 被引量：1

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摘要 近年来，随着组织工程技术的研究进展，人们尝试用皮肤组织工程的方法体外重建肿瘤组织^[1]。因去表皮的真皮（de—epidermized dermis，DED）具有三维胶原结构，并含基底膜成分，符合肿瘤细胞在皮肤组织中生长的微环境^[2]。
作者 吕宇 陆洪光
机构地区 贵阳医学院附属医院皮肤科
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2010年第4期273-274,共2页 Chinese Journal of Dermatology
基金 国家自然科学基金（30571685）
关键词 皮肤组织工程 基质金属蛋白酶-2 恶性黑素瘤 体外模型 组织工程技术 基底膜成分 肿瘤组织 体外重建
分类号 R739.5 [医药卫生—肿瘤]
  • 相关文献

参考文献6

  • 1Maaser K,Wolf K,Klein CE,et al.Functional hierarchy of simultaneously expressed adhesion receptors:integrin alpha2betal but not CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagnn matrices.Mol Biol Cell,1999,10(10):3067-3079.
  • 2Eves P,Katerinaki E,Simpson C,et al.Melanoma invasion in reconstructed human skin is influenced by skin cells-investigation of the role of proteolytic enzymes.Clin Exp Metastasis,2003,20(8):685-700.
  • 3彭琳琳,陆洪光.MV3细胞系体外构建恶性黑素瘤模型的研究[J].中华皮肤科杂志,2009,42(2):97-100. 被引量：5
  • 4Hofmann UB,Westphal JR,Van Kraats AA,et al.Expression of integrin alpha(v)beta(3)correlates with activation of membranetype matrix metalloproteinase-1(MT1-MMP)and matrix metalloproteinase-2(MMP-2)in human melanoma cells in vitro and in vivo.Int J Cancer,2000,87(1):12-19.
  • 5Gaggioli C,Sahai E.Melanoma invasion-current knowledge and future directions.Pigment Cell Res,2007,20(3):161-172.
  • 6V(a)is(a)nen AH,Kallioinen M,Turpeenniemi-Hujanen T.Comparison of the prognostic value of matrix metalloproteinases 2 and 9 in cutaneous melanoma.Hum Pathol.2008,39(3):377-385.

二级参考文献8

  • 1牟霞,陆洪光,吴承龙,余德厚,程波,汪宇.B16小鼠皮肤恶性黑素瘤模型的建立[J].中华皮肤科杂志,2004,37(10):613-613. 被引量：7
  • 2Masser K, Wolf K, Klein CE, et al. Functional hierarchy of simultaneously expressed adhesion receptors: integrin α2β1 but not CD44 mediates MV3 melanoma cell migration and matrix reorganization within three-dimensional hyaluronan-containing collagen matrices. Mol Biol cell, 1999, 10( 10): 3067-3079.
  • 3Eves P, Katerinaki E, Simpson C, et al. Melanoma invasion in reconstructed skin is influenced by skin cells investigation of the role proteolytic enzymes. Clinical Experimental Metastasis, 2003, 20(8): 685-700.
  • 4Lu H, Rollman O. Fluorescence imaging of reepithelialization from skin explant cultures on acellular dermis. Wound Rep Reg, 2004, 12(5): 575-586.
  • 5Pasco S, Ramont L, Maquart FX, et al. Control of melanoma progression by various matrikines from basement membrane macromolecules. Crit Rev Onvol Hematol, 2004, 49 (3): 221-233.
  • 6Hofmann UB, Houben R, Brocker EB, et al. Role of matrix metalloproteinases in melanoma cell invasion. Biochimie, 2005, 87(3-4): 307-314.
  • 7Van Kilsdonk JW, Wilting RH, Bergers M, et al. Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. Cancer Res, 2008, 68( 10): 3671-3679.
  • 8王新宇,陆洪光,卜晓琳,彭琳琳,赵志国,汤朝武,王洪涛.应用表皮干细胞与去表皮的真皮体外构建组织工程皮肤[J].中华皮肤科杂志,2008,41(7):458-461. 被引量：3

共引文献4

同被引文献36

  • 1郭丽丽,陈言汤,牛扶幼,刘林嶓.病理性瘢痕组织中基质金属蛋白酶-1、金属蛋白酶组织抑制剂-1、血小板源性生长因子、增殖细胞核抗原的表达[J].郑州大学学报（医学版）,2006,41(6):1027-1030. 被引量：4
  • 2Chakraborti S,Mandai M,Das S,et al.Regulation of matrix metalloproteinase:an overview[J].Molecular and Cellular Biochemistry,2003,253(1-2):269-285.
  • 3Roy R,Yang J,Moses MA.Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer[J].J Clin Oncol,2009,27(31):5287-5297.
  • 4Kerkela E,Saarialho-Kere U.Matrix metalloproteinases in tumor progression:focus on basal and squamous cell skin cancer[J].Exp Dermatol,2003,12(2):109-125.
  • 5Kang S,Cho S,Chung JH,et al.Inflammation and extracellular matrix degradation mediated by activated transcription factors nuclear factor-kappaB and activator protein-1 in inflammatory acne lesions in vivo[J].American J of Pathol,2005,166(6):1691-1699.
  • 6Sato H,Takino T.Coordinate action of membrane-type matrix metalloproteinase-1(MT 1-MMP) and MMP-2 enhances pericellular proteolysis and invasion[J].Cancer Sci,2010,101(4):843-847.
  • 7Libra M,Scalisi A,Vella N,et al.Uterine cervical carcinoma:role of matrix metalloproteinases(review)[J].Int J Oncol,2009,34(4):897-903.
  • 8Waleh NS,Murphy BJ,Zaveri NT.Increase in tissue inhibitor of metalloproteinase-2(TIMP-2) levels and inhibition of MMP-2 activity in a metastatic breast cancer cell line by an anti-invasive small molecule SR13179[J].Cancer Lett,2010,289(1):111-118.
  • 9Johnson JL.Matrix metelloprteineses:influence on smooth muscle cells and atherosclerotic plaque stability[J].Expert Rev Cardiovasc Ther,2007,5(2):265-282.
  • 10Jalian HR,Liu PT,Kanchanapoomi M,et al.All-trans retinoic acid shifts Propionibacterium acnes-induced matrix degradation expression profile toward matrix preservation in human monocytes[J].J Invest Dermatol,2008,128(12):2777-2782.

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中华皮肤科杂志
2010年 第4期

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