摘要
目的:探讨葛根总黄酮对四氯化碳(CCl4)所致大鼠慢性肝损伤的保护作用,同时进一步探讨葛根总黄酮抗肝损伤可能的作用机制。方法:用CCl4制备慢性肝损伤动物模型。测定血清中天门冬氨酸氨基转移酶(AST)和丙氨酸氨基转移酶(ALT)、透明质酸(HA)含量,并观察肝组织形态学变化。结果:葛根总黄酮能显著降低CCl4所致大鼠血清AST、ALT和HA含量的升高(P(0.01);减轻对肝细胞的病理性损害。结论:葛根总黄酮对CCl4所致的大鼠慢性肝损伤具有一定的保护作用,其机制可能与清除氧自由基、抗脂质过氧化和抗纤维化有关。
Objective ：To observe the protective effects of Radices Puerarire Total Flavone on carbon tetrachloride（ CCl4 ） induced chronic hepatic injury of rats, and to explore its Possible mechanisms. Methods ： chronic hepatic injury model was induced by CCl4. then the ac- tivities of aspartate transaminase（AST）, alanine transaminase （ALT） and hyaluronic acid （HA） in blood serum were detected. Mean- while the pathology of the liver was observed with microscopy. Results ; Radices Puerarire Total Flavone significantly decrease the eleva- tions of serum ALT, AST and HA activities in chromic liver injuries induced by CCl4 in Wistar rats, The optical microscope results show ： the fiber increasing and hepatocytes denaturation necrosis of high-dose and medium-dose treat groups are serious decreasing. Con- clusion：It is revealed that Radices Puerarire Total Flavone could prevent CCl4 from inducing chronic liver injury. The mechanisms are possibly related with inhibiting lipid peroxidation and scavenging oxygen free radicals.
出处
《江西中医学院学报》
2010年第1期70-72,共3页
Journal of Jiangxi College of Traditional Chinese Medicine
关键词
葛根总黄酮
慢性肝损伤
保护作用
Radices Puerarire Total Flavone
Liver injury
Protective effect
