摘要
目的评价FOLFOX方案在结直肠癌术后化疗中的疗效和毒副反应。方法42例结肠癌术后患者,给予L-OHP85mg/m2静脉滴入,持续2h,第1d;CF200mg/m2静脉滴入,持续2h,第1～2d;5-FU400mg/m2,静脉点滴,第1～2d;5-FU600mg/m2,静脉泵入,持续22h,第1～2d,每2周重复。结果42例患者中位肿瘤进展时间26.9个月。毒副反应主要是末梢神经毒性、恶心呕吐、骨髓抑制及静脉炎等,患者均可耐受。结论FOLFOX方案在结直肠癌术后化疗中有良好的疗效,毒副反应可以耐受。
Objective： To evaluate the therapeutic effect and toxicity of FOLFOX in colorectal cancer after operation. Methods： 42 patients with colorectal cancer after operation received L-OHP 85 mg/m^2 iv infusion 2 hours for 1 day;CF200 mg/m^2 intravenous push 2 hours for 1 to 2 days ; 5-Fu 400 mg/m^2 intravenous drop infusion for 1-2 days, 5-Fu 600 mg/m^2, sustained intravenous infusion for 22 hours for 1-2 days.This regimen was repeated every 2 weeks. Results： The median time of tumor progression of 42 patients was 26.9 months. The major toxicities included nausea and vomiting, neurosensory toxicity, bone marrow depression and peripheral phlebitis, but they were tolerable for patients. Conclusion： The combination of FOLFOX is an effective and tolerable treatment for postoprative colorectal cancer.
出处
《井冈山大学学报（自然科学版）》
2010年第2期78-80,共3页
Journal of Jinggangshan University (Natural Science)
