摘要
目的:研究双环醇对利福平和异烟肼血药浓度及药代动力学参数的影响。方法:应用HPLC法测定与双环醇联用前后利福平和异烟肼的血药浓度,以DAS 2.0药代动力学程序拟合药动学参数。结果:双环醇与利福平合用、双环醇与异烟肼合用、双环醇与利福平和异烟肼同时合用的各时间点中,除异烟肼6 h的血药浓度三药合用组与其他组有显著性差异(P<0.05)之外,其余时间点的血药浓度值在各组间均无显著性差异(P>0.05);药动学参数AUC(药时曲线下面积)(0-t)、AUC(0-∞)、MRT(体内平均驻留时间)(0-t)、MRT(0-∞)、t1/2 z(半衰期)、tm ax(达峰时间)、CLz/F(清除率)、Vz/F(表现分布容积)、Cm ax(血药峰浓度)各组间均无显著性差异(P>0.05)。结论:双环醇与利福平合用或与异烟肼合用,以及与利福平和异烟肼两药合用,均未见对利福平和异烟肼药动参数有明显影响。
Objective ： To study the effects of bieyclol on plasma concentrations and pharmacokinetics of rifampin and isoniazid in rats. Methods： The plasma concentrations of rifampin and isoniazid were determined by high performance liquid chromatography （HPLC） before and after the administration of bicyclol. Pharmacokinetic parameters were evaluated by a pharmaeokinetics software package of DAS 2.0. Results： When isoniazid and rifampin were administered with bieyclol respectively or these three drugs were co- administered, there were no significant difference in concentrations of isoniazid and rifampin at all time points（ P 〉 0.05 ）except that at six - hour point at which the concentration of isoniazid in the three - drug combination was significantly different from those of the two - drug combinations （ P 〈 0.05 ）. There were also no significant differences in pharmacokinetic parameters, such as AUC（0 - t） , AUC（0-∞ ）, MRT（0-t）, MRT（0-∞）, t1/2t, tmax, CLx/F, Vx/F and Cmax between different combinations（ P 〉 0.05 ）. Conclusions： Bicyclol will not exert influence on pbarmacokinetic profiles of isoniazid and rifampiu when it is co - administered with these two drugs repectively.
出处
《天津药学》
2010年第2期4-7,共4页
Tianjin Pharmacy
关键词
利福平
异烟肼
双环醇
药代动力学
rifampin, isoniazid, bicyclol, pharmacokinetics, plasma concentration
