摘要
对１０例健康志愿者静脉恒速滴注氧氟沙星２００ｍｇ（３０ｍｉｎ）注射液后的药物动力学进行了研究。用高效液相色谱法及微生物法分别对血清及尿中氧氟沙星进行测定。其体内过程符合二室开放模型，主要药动学参数分别是：滴注完时浓度Ｃ０为５．１５±１．６３ｍｇ／Ｌ，清除相半衰期为４．８６±０．１８ｈ，ＡＵＣ为１５．８９±２．８６ｈ·ｍｇ／Ｌ，中央室表现分布容积Ｖｃ为３５．０６±１１．０４Ｌ，０～２４小时内尿中排泄原药的７８．９％±１０．９％。
A 200mg dose of Ofloxacin was given as a 30 minute intravenous infusionto each of ten heaIthy volunteers.Plasma and urine levels of ofloxacin were assayed bybioassay and HPLC. The plasma course of ofloxacin could be best discribed by an opan twocompartment model.Its main parameters were as fOllows:C0=5.15±1.63mg/L;t(1/2) 4.86±0.18h;AUC=15.89±2.86 h·mg/L Vc=35.06±11.04L.The mean cumulative excretion of 24 h urine were 78.90%±10.90%.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1995年第1期59-62,共4页
Chinese Journal of Antibiotics
