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6-碘取代的白杨素衍生物合成及其抗癌活性 被引量：3

Synthesis and Anticancer Activities of 6-Iodo-Chrysin Derivatives
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摘要 目的研究6-碘取代白杨素衍生物的体外抗癌活性。方法合成6-碘取代的白杨素衍生物．并通过MTT法检测其对人急性粒细胞性白血病（HL-60）细胞、人结肠癌（HT-29）细胞和人胃癌（SGC-7901）细胞增殖的抑制作用。结果合成了2个6-碘取代白杨素衍生物。结论6-碘取代白杨素衍生物具有良好的抗癌活性（IC50=1．87—6．09μmol／L）。 Objective To study the antieancer activity of 6 -iodo -chrysin derivatives. Methods 6 -Iodo - ehrysin derivatives were prepared and their antieaneer activities in vitro were evaluated by the standard MTT method. Restilts Two 6 - iodo - chrysin derivatives were synthesized. Conclusion 6 - Iodo - chrysin derivatives possessed the potent anticaneer activity （ IC50 = 1.87 - 6.09 μmol/L）.
作者 郑兴 刘毅 许雪梅 罗星 王小平 杜青梅 廖端芳
机构地区 南华大学药理教研室 南华大学科研兴趣小组
出处 《南华大学学报（医学版）》 2010年第2期200-202,共3页 Journal of Nanhua University(Medical Edition)
基金 国家教育部重点项目(20809) 湖南省自然科学基金(07JJ6157)资助
关键词 白杨素 衍生物 碘代 抗癌活性 chrysin derivatives iodonated antieancer activities
分类号 R978.7 [医药卫生—药品]
  • 相关文献

参考文献10

  • 1Meng-Shih Weng,Yuan-Soon Ho,Jen-Kun Lin.Chrysin induces G1 phase cell cycle arrest in C6 glioma cells through inducing p21Waf1/Cip1 expression:involvement of p38 mitogenactivated protein kinase[J].Biochem Phmacol,2005,69:1815-1827.
  • 2Kyung Jin Woo,Yong-Jin Jeong,Jong-Wook Park,et al.Chrysin-induced apoptosis is media-ted through caspase activation and Akt inactivation in U937 leukemia cells[J].Biochem Biophys Res Commun,2004,325:1215-1222.
  • 3Kyung Jin Woo,Yong-Jin Jeong,Hiroyasu Inoue,et al.Chrysin suppresses lipopolysaccharide -induced cyclooxygenase-2 expression through the inhibition of nuclear factor for IL-6 (NF-IL6) DNA-binding activity[J].FEBS Lett,2005,579:705-711.
  • 4Zanoli P,Avallone R,Baraldi M.Behavioral characterisation of the flavonoids apigenin and chrysin[J].Fitoterapia,2000,71:S117-S123.
  • 5康颖,刘红光,曾谷清,谷依学.白杨素对人胃癌SGC-7901细胞增殖与凋亡的影响[J].肿瘤防治研究,2007,34(9):656-658. 被引量：12
  • 6Xing Zheng,Weidong Meng,Yangyan Xu,et al.Synthesis and anticancer effect f chrysin derivatives[J].Bioorg Med Chem Lett,2003,13:881-885.
  • 7Zembower DE,Zhang HP.Total synthesis of robustaflavone,a potential anti-hepatitis B agent[J].J Org Chem,1998,63,9300-9305.
  • 8Tsuji PA,Winn RN,Thomas Walle.Accumulation and metabolism ofthe anticancer flavonoid 5,7-dimethoxyflavone compared to its unmethylated analog chrysin in the Atlantic killifish[J].Chem-Biol Interact,2006,164:85-92.
  • 9Xing Zheng,Jianguo Cao,Weidong Meng,et al.Synthesis and anticancer effect of B-ring trifluoromethylated flavonoids[J].Bioorg Med Chem Lett,2003,13:3423-3427.
  • 10Xing ZHENG,Jian Guo CAO,Duan Fang LIAO,Bing Yang ZHU,Hui Ting LIU.Synthesis and Anticancer Effect of gem-Difluoromethylenated Chrysin Derivatives[J].Chinese Chemical Letters,2006,17(11):1439-1442. 被引量：21

二级参考文献10

  • 1彭创,汤恢焕.Bcl-2和Bax在胆管癌中的表达及相关研究[J].湘南学院学报（自然科学版）,2004,6(4):59-62. 被引量：1
  • 2Ting Zhang,Xiaolan Chen,Lingbo Qu.Chrysin and its phosphate ester inhibit cell proliferation and induce apoptosis in Hela cells[J].Bioorg Med Chem,2004,12(23):6097-6105.
  • 3Kyung Jin Woo,Jeong Yong-Jin,Park Jong Wook.Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells[J].Biochem Biophys Res Commun,2004,325(4):1215-1222.
  • 4Schattner EJ,Friedman SM,Casali P.Inhibition of Fas-mediated apoptosis by antigen:implications for lymphomagenesis[J].Autoimmunity,2002,35(4):283-289.
  • 5Sherr CJ.The Pezcoller Lecture:cancer cell cycle revisited[J].Cancer Res,2000,60(14):3689.
  • 6Sun SC,Xiao G.Deregulation of NF-kappaB and its upstream kinases in cancer[J].Cancer Metastasis Rev,2003,22(4):405-422.
  • 7Karin M,Cao Y,Greten FR,et al.NF-kappaB in cancer:from innocent by stander to major culprit[J].Nat Rev Cancer,2002,2(4):301-310.
  • 8Mayo MW,Baldwin AS.The transcription factor NF-kappaB:control of oncogenesis and cancer therapy resistance[J].Biochim Biophys Acta,2000,1470(2):55-62.
  • 9Kelly M.Regula,Karen Ens,Lorrie A,Kirshenbaum.IKKβIs required for NFкB mediated Bcl-2 activation in ventricular myocytes[J].Biol Chem,2002,10(4):1074-1076.
  • 10Matsushita H,Morishita R,Nata T,et al.Hypoxia-induced endothelial apoptosis through nuclear factor-kB (NF-κB)-mediated bcl-2 suppression[J].Circulation Research,2000,86(9):974-981.

共引文献28

同被引文献32

引证文献3

二级引证文献21

南华大学学报（医学版）
2010年 第2期

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