摘要
目的:研究5-烯丙基-7-二氟亚甲基白杨素(ADFMChR)对人肺癌A549细胞移植瘤生长的抑制作用。方法:建立人肺癌A549裸鼠移植瘤模型,测定荷人肺癌裸鼠的移植瘤大小;HE染色,光学显微镜下观察移植瘤组织形态学特征。结果:ADFMChR对肺癌移植瘤生长具有显著抑制作用。HE染色镜下观察,ADFMChR处理的人肺癌裸鼠移植瘤组织内细胞退形性变,核固缩,核碎裂。结论:ADFMChR显著抑制人肺癌A549细胞裸鼠移植瘤的生长,呈剂量依赖性。
Objective： To investigate the inhibitory effects of 5-allyl-7-gendifluoromethylenechrysin （ADFMChR） on the growth of human lung carcinoma A549 xenografts.Methnds： Human lung carcinoma A549 xenograft in nude mouse model was established to investigate the volume xenografts. HE staining was utilized to observe the histomorphology change of the xenografts. Results： ADFMChR produced dose-dependent growth inhibition of s.c. implanted A549 tumor xenografts in nude mice.HE staining showed that the cells of retreat-change, pyknosis, karyorrhexis in the tissue of human lung carcinoma xenograft in nude mouse model after treatment with ADFMChR. Conclusion： ADFMChR significantly inhibited the growth of human lung carcinoma A549 cells xenografts in BALB/e-nu mice. in a dose-dependent manner.
出处
《中国医药导刊》
2010年第6期1005-1007,共3页
Chinese Journal of Medicinal Guide
基金
湖南省科技厅2008年资助项目(负责人:许金华)
衡阳市科技局资助项目(2005KS01-003)
