摘要
目的比较法莫替丁与泮托拉唑预防重度颅脑损伤并发应激性消化道出血的经济效果。方法将240例重度颅脑损伤的患者随机分成3组,法莫替丁组80例给予法莫替丁治疗5～40 d,泮托拉唑组80例给予泮拉唑治疗5～10 d,对照组未使用预防应激性溃疡的药物,对比其应激性溃疡的预防用药成本及发生率。结果法莫替丁组、泮托拉唑组与对照组的应激性溃疡的发生率分别为14%,9%和26%,3组比较有显著性差异(P均<0.05);成本-效果比法莫替丁组为94.14,泮托拉唑组为1 104.66,2组比较有显著性差异(P<0.05)。结论重度颅脑损伤后应用法莫替丁与泮托拉唑均能抑制胃酸,预防应激性溃疡,法莫替丁更为经济。
Objective It is to evaluate cost effectiveness analysis of famotidine and pantoprazole for the prevention of severe craniocerebral injury complicated by upper gastrointestinal bleeding.Methods 240 patients with severe craniocerebral injury were randomly divided into 3 groups with 80 cases each group.Famotidine group was treated by famotidine for 5 to 40 days;pantoprazole group was treated by pantoprazole for 5 to 10 days;control group was given nothing for prevention of stress ulcer.The cost and prevention effectiveness were analyzed.Results The incidence rates of stress ulcer of famotidine group,pantoprazole group and control group were 14%,9% and 26% respectively,there was significant difference（P0.05）;and the cost effectiveness rate were 94.14,1104.66 and 0 respectively,there was significant difference（P0.05）.Conclusion Famotidine and pantoprazole are effective option for the prevention of severe craniocerebral injury complicated by upper gastrointestinal bleeding,but famotidine is more economic.
出处
《现代中西医结合杂志》
CAS
2010年第15期1833-1834,1851,共3页
Modern Journal of Integrated Traditional Chinese and Western Medicine
关键词
重度颅脑损伤
上消化道出血
法莫替丁
泮托拉唑
成本-效果分析
severe craniocerebral injury
upper gastrointestinal bleeding
famotidine
pantoprazole
cost effectiveness analysis
