摘要
目的:评价法莫替丁、雷尼替丁及奥美拉唑治疗急性脑出血并发应激性上消化道出血的疗效和经济学效果。方法:将180例脑出血并发应激性上消化道出血的患者按给药方案分成法莫替丁组、雷尼替丁组、奥美拉唑组,分别给予法莫替丁、雷尼替丁、奥美拉唑治疗5d,观察疗效,并进行药物经济学分析。结果:法莫替丁组、雷尼替丁组、奥美拉唑组治疗上消化道出血的总有效率分别为87.3%、76.7%、93.8%,成本分别为58、18、430元,成本-效果比分别为66.44、23.47、458.42;相对于雷尼替丁组,法莫替丁组、奥美拉唑组的增量成本-效果比分别为377.36、2409.36。结论:法莫替丁治疗急性脑出血并发应激性上消化道出血最为经济、有效。
OBJECTIVE： To evaluate the curative and economic effects of famotidine, ranitidine and omeprazole for acute cerebral hemorrhage complicated by upper gastrointestinal bleeding. METHODS： 180 patients were randomized to famotidine group, ranitidine group and omeprazole group and treated with relevant drugs for 5 days. The curative efficacy were recorded and cost-effectiveness was analyzed. RESULTS： The cost of famotidine group, ranitidine group and omeprazole group were 58 yuan, 18 yuan and 430 yuan with total effective rate of 87.3%, 76.7% and 93.8%, respectively. The cost-effectiveness ratio of three groups were 66.44,23.47,458.42, respectively. Incremental cost-effectiveness ratio of famotidine group and omeprazole group were 377.36,2 409.36, respectively as compared with ranitidine group. CONCLUSION： Famotidine is an economical and effective option for acute cerebral hemorrhage complicated by upper gastrointestinal bleeding.
出处
《中国药房》
CAS
CSCD
北大核心
2010年第10期871-873,共3页
China Pharmacy
关键词
脑出血
上消化道出血
法莫替丁
雷尼替丁
奥美拉唑
成本-效果分析
Cerebral hemorrhage
Upper gastrointestinal bleeding
Famotidine
Ranitidine
Omeprazole
Cost-effectiveness analysis
