摘要
目的探讨安神汤联合齐拉西酮治疗以阴性症状为主精神分裂症的疗效和安全性。方法将60例以阴性症状为主精神分裂症患者随机分为2组各30例,研究组给予安神汤合并齐拉西酮治疗,对照组单用齐拉西酮治疗,2组观察治疗12周;用阳性和阴性综合征量表(PANSS)和不良反应量表(TESS)评定临床疗效和安全性。结果治疗12周后,研究组显效率高于对照组。PANSS评分较治疗前下降,且低于同期对照组,有显著性差异(P<0.05或0.01),但TESS评分与对照组比较有显著性差异(P>0.05)。结论安神汤联合齐拉西酮治疗以阴性症状为主精神分裂症疗效较齐拉西酮单用优越,且不增加不良反应。
Objective It is to approach the curative effect and safety of Anshentang combined with ziprasidone in treatment of schizophrenia with negative symptoms.Methods 60 patients with negative schizophrenia diagnosed according to CCMD-3 criteria were randomly divided into two groups with 30 cases each other.The study group was treated with Anshentang combined with ziprasidone,and the control group was treated with ziprasidone alone,the period of treatment is 12 weeks.The Positive and Negative Syndrome Scale（PANSS） and Treatment Emergent Side effect Scale（TESS） were used to evaluate the effect and side effect respectively.Results After 12 weeks,the clinical effect in the study group was significantly better than that in the control group.The scores of PANSS were decreased in the study group,and were lower significantly than those in the control group（P0.01 or 0.05）.There was no significant difference in the score of TESS between the two groups（P0.05）.Conclusion Anshentang combined with ziprasidone has better effect in treatment of schizophrenia with negative symptoms than ziprasidone alone and it is rather safe.
出处
《现代中西医结合杂志》
CAS
2010年第15期1831-1832,共2页
Modern Journal of Integrated Traditional Chinese and Western Medicine
