期刊文献+

齐拉西酮治疗以阴性症状为主的精神分裂症对照研究

原文传递
导出
摘要 目的评价齐拉西酮对以阴性症状为主的精神分裂症的疗效和副作用。方法对60例以阴性症状为主的精神分裂症的住院患者按治疗药物不同分为2组,每组30例,分别服用齐拉西酮和氯氮平,治疗8周。采用阴性和阳性量表(PANSS)、阴性症状量表(SANS)和不良反应量表(TESS)等评定疗效和副作用。结果齐拉西酮组和氯氮平组的疗效相当,但副作用明显轻于氯氮平。结论齐拉西酮是一种安全有效的抗精神病药,对精神分裂症的阴性症状有显著的疗效,值得临床推广使用。
出处 《中国医师杂志》 CAS 2008年第5期696-697,共2页 Journal of Chinese Physician
  • 相关文献

参考文献3

二级参考文献35

  • 1Capuano B, Crosby IT, Lloyd EJ. Schizophrenia: genesis, receptorology and current herapeutics[ J ]. Curr Med Chem, 2002,9(5) : 521 - 548.
  • 2Schmidt AW, Lebel LA, Howard HR Jr, et al. Ziprasidone: a novel antipsychotic agent with aunique human receptor binding profile[ J ]. Eur J Pharmacol, 2001,425 (3) : 197 - 201.
  • 3Miceli JJ, Wilner KD, Hansen RA, et al. Single- and multipledose pharrnacokinetics of 2iprasidone under non-fasting conditions in healthy male volunteers [ J ]. Br J Clin Pharmacol, 2000,49(Suppl 1) :S5 - S13.
  • 4Miceli JJ,Hunt T,Cole MJ, et al. The pharmacokinetics of CP-88,059 in healthy male volunteers following oral and intravenous administration(abstract) [ J ]. Clin Pharmacol Ther, 1994,62 :142.
  • 5Prakash C,Kamel A,Gummerus J, et al. Metabolism and excretion of a new antipsychotic drug, ziprasidone, in humans[J].Drug Metab Dispos, 1997,25(7) :863 - 872.
  • 6Wilner KD, Tensfeldt TG, Baris B, et al. Single- and multipledose pharmacokinetics of ziprasidone in healthy young and elderly volunteers[J]. Br J Clin Pharmacol,2000,49(Suppl 1 ) : S15 -S20.
  • 7Aweeka F, Jayesekara D, Horton M, et al. The pharmacokinetics of ziprasidone in subjects with normal and impaired renal function[J]. Br J Clin Pharmacol,2000,49(Suppl 1) :S27 - S33.
  • 8Everson G, Lasseter KC, Anderson KE, et al. The pharmacokinetics of ziprasidone in subjects with normal and impaired hepatic function[J]. Br J Clin Pharmacol, 2000,49 ( Suppl 1 ) : S21 -S26.
  • 9Miceli J J, Anziano RJ, Robarge L, et al. The effect of carbamazepine on the steady-state pharmacokinetics of ziprasidone in healthy volunteers [ J ]. Br J Clin Pharmacol, 2000, 49 ( Suppl1) :S65 - S70.
  • 10Miceli J J, Smith M,Robarge L, et al. The effects of ketoconazole on ziprasidone pharmacokinetics--a placebo-controlled crossover study in healthy volunteers [ J ]. Br J Clin Pharmacol, 2000,49(Suppl 1) :S71 - S76.

共引文献155

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部