摘要
目的研究厄贝沙坦在比格犬体内的药代动力学。方法给比格犬口服厄贝沙坦片,用超快速液相色谱法检测厄贝沙坦的浓度。结果主要药代动力学参数如半衰期、峰浓度、AUC0～48分别为:(13.96±3.26)h、(2582.85±1265.69)ng/ml、(7951.13±2794.07)ng.h/ml。结论该方法灵敏、准确,能快速检测比格犬血浆中厄贝沙坦浓度。
Objective To analyze the pharmacokinetics of irbesartan tablet in beagle dogs. Meth- ods Six healthy subjects received a single oral dose of 300 mg irbesartan tablet. The plasma concentrations of irbesartan were determined using ultra-fast liquid chromatography. Results The main pharmacokinetics parameters of irbesartan were： tl/2 13.96 ± 3.26 h, Cmax 2582.85 ± 1265.69 ng/ml, AUC0-48 7951.13 ± 2794.07 ng-h/ml. Conclusion The method established in this study allows for highly sensitive, selec- tive and accurate determination of plasma concentration of plasma irbesartan in dogs.
出处
《东南国防医药》
2010年第2期102-103,106,共3页
Military Medical Journal of Southeast China
关键词
厄贝沙坦
超快速液相色谱
药代动力学
irbesartan
ultra-fast liquid chromatography
pharmacokinetics
