摘要
目的观察檀香挥发油对豚鼠离体回肠和小鼠小肠推进的影响。方法采用离体实验方法、炭末推动法,以正常、新斯的明负荷、肾上腺素负荷为研究模型。结果檀香挥发油对豚鼠离体回肠自发活动有抑制作用,且对乙酰胆碱、组胺、氯化钡所致的离体肠痉挛有对抗作用(P<0.01),檀香挥发油可显著拮抗新斯的明负荷小鼠的小肠运动(P<0.01)。结论檀香挥发油对小鼠小肠运动亢进有抑制作用。
Objective To study the effect of sandalwood essential oil on isolated ileum smooth muscle of guinea pigs and the small intestine movement function of mice.Methods We used the experiment method of isolating ileum smooth muscle of guinea pigs and intestine propulsion of carbon ink in mice.We constructed the models of healthy mice,neostigminetrested mice and adrenaline-loaded mice.Results Sandalwood essential oil had an inhibitory effect on the spontaneous movement of guinea pigs isolated ileum and an antagonistic action on intestinal spasm caused by acetylcholine,histamine and barium chloride（P〈0.01）.The oil was found to have a significantly antagonistic effect on small intestine movement in neostigminetrested mice（P〈0.01）.Conclusion Sandalwood essential oil has an inhibitory action when the small intestine movement is hyperactive.
出处
《西安交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第3期366-369,共4页
Journal of Xi’an Jiaotong University（Medical Sciences）
基金
国家科技部973资助项目:中药药性理论相关基础问题研究(2007CB512603)~~
关键词
檀香挥发油
离体肠
小肠推进
sandalwood essential oil
isolated intestine
small intestine propulsion
