摘要
目的：观察白术对动物胃肠运动的影响并探讨其作用机制。材料与方法：以豚鼠回肠收缩强度为指标，观察不同浓度的白术水煎剂对肠平滑肌收缩的影响；用碳末胶液在小鼠小肠内推进的距离占小肠全长百分数为指标，观察白术对小鼠胃肠推进运动的影响。结果：浓度为０．ｌμｍ的白术水煎剂１．０ｍｌ可轻度抑制回肠的收缩；较大浓度的白术水煎剂１μｍ、１０μｍ、０．１μｍ、１ｍＭ、１０ｍＭ则能显著加强回肠的收缩，并呈量效反应关系。０．１ｍｇ／１０ｇ体重的白术煎剂对小鼠胃肠推进运动有显著加强作用；阿托品能明显抑制白术的兴奋作用；酚妥拉明可部分拮抗白术的兴奋效应；心得安对白术的兴奋效应影响不大。结论：大剂量白术水煎剂能促进动物的胃肠运动，随剂量加大而作用加强。这种效应主要通过胆碱能受体介导，α受体可能通过某种间接途径参与其调节机制．
Purpose:To study the
effect and mcehanism of Rhizoma atractylodis macrocephalae(RAM)on gastrointestinal motility
in animals. Materials and methods:The varied concentrations of RAM on the spontaneous
contraction of isolated guinea pig ileum was studied;The effect of RAM on the gastrointestinal
propulsive movementwas assessed by the travelled distance of colloidal charcoal powder
along the smallintestine in mice. Results:RAM 6.25%inhibited modestly the spontaneous
contraction;RAM I2.5% or higher concentrations could significantly augment the
spontaneouscontraction and was dose-dependent.RAM 0.1ml/10g weight increased markedly
thepropulsive movement but was abolished by atropine; Regitine antagoniaed theincreased
gastrointestinal propulsive movement and Propranolol had no effect onRAM. Conclusion∶
RAM has a stimulating effect on the propulsive movement ofgastrointestinal tract,which may be
mediated through M recpetor or indirectly thealpha receptor.
出处
《中华消化杂志》
CAS
CSCD
北大核心
1996年第5期261-264,共4页
Chinese Journal of Digestion
关键词
白术
中医药疗法
胃肠推进运动
胃肠功能紊乱
Rhizoma atractylodis
macrocephalae Isolated guinea pigileum propulsive movement M receptor α receptor
