摘要
目的探讨直肠癌根治术后局部复发的相关临床病理因素，以提高直肠癌根治疗效。方法回顾性分析1995年1月至2002年12月257例直肠癌根治术后患者的临床病理资料，应用两分类反应变量Logistic回归（前进法）建立单因素和多因素回归分析模型，探讨各临床病理特征与术后局部复发的关系。结果直肠癌根治术后局部复发率为18．7％，中位时间14．6（2～63）个月；术后2年内复发率75．0％（36／48），3年内复发率95．8％（45／48）。单因素回归分析显示年龄、Dukes分期、淋巴结转移、癌胚抗原水平与直肠癌根治术后局部复发有关（均P〈0．05）；多因素回归分析显示年龄、淋巴结转移是影响直肠癌根治术后局部复发的重要因素（均P〈0.05）。结论年龄和淋巴结转移是影响直肠癌患者术后局部复发重要的因素，加强早期诊断和科学、规范的治疗有望改善直肠癌预后。
Objective To investigate the clinicopathologic factors related to local recurrence following curative surgery for rectal cancer and explore the ways to improve the efficacies. Methods A total of 257 post-operative cases of rectal cancers from January 1995 to December 2002 were recruited. And the relation of each clinicopathologic characteristic and local post-operative recurrence was retrospectively investigated. The clinicopathologic factors and follow-up data were analyzed by uni and multi-factorial regression model by logistic regression. Results The total local recurrence rate of rectal cancer after radical operation was 18.7%, 75.0% （36/48）within 2 years and 95.8% （45/48）within 3 years, the median time was 14.6 months （ range ： 2-63）. Univariate analysis showed that age, Dukes＇ stage, lymph node metastasis and level of CEA were significantly associated with the local post-operative recurrence （ P 〈 0. 05 ）. Mutivariate analysis showed that age and lymph node metastasis were closely related with the local post- operative recurrence （P 〈 0. 05 ）. Conclusion Lymph node metastasis and age are very important prognostic factors for the local post-operative recurrence. It is possible to improve the prognosis of rectum cancer by making an early diagnosis and offering a scientific standard therapy.
出处
《中华医学杂志》
CAS
CSCD
北大核心
2010年第14期985-987,共3页
National Medical Journal of China
关键词
直肠肿瘤
肿瘤复发
局部
回归分析
Rectal neoplasms
Neoplasm recurrence, local
Regression analysis
